Title |
Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish
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Published in |
BMC Genomics, November 2010
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DOI | 10.1186/1471-2164-11-643 |
Pubmed ID | |
Authors |
Jared V Goldstone, Andrew G McArthur, Akira Kubota, Juliano Zanette, Thiago Parente, Maria E Jönsson, David R Nelson, John J Stegeman |
Abstract |
Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function. CYP enzymes catalyze oxidative transformation leading to activation or inactivation of many endogenous and exogenous chemicals, with consequences for normal physiology and disease processes. Many CYPs potentially have roles in developmental specification, and many chemicals that cause developmental abnormalities are substrates for CYPs. Here we identify and annotate the full suite of CYP genes in zebrafish, compare these to the human CYP gene complement, and determine the expression of CYP genes during normal development. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 2% |
United States | 4 | 1% |
Brazil | 3 | <1% |
Canada | 1 | <1% |
Germany | 1 | <1% |
Spain | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 303 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 69 | 22% |
Researcher | 54 | 17% |
Student > Master | 52 | 16% |
Student > Bachelor | 31 | 10% |
Professor > Associate Professor | 16 | 5% |
Other | 45 | 14% |
Unknown | 52 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 99 | 31% |
Biochemistry, Genetics and Molecular Biology | 38 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 34 | 11% |
Environmental Science | 29 | 9% |
Medicine and Dentistry | 17 | 5% |
Other | 38 | 12% |
Unknown | 64 | 20% |