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Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

Overview of attention for article published in Epigenetics & Chromatin, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#45 of 499)
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

32 tweeters
1 Redditor


165 Dimensions

Readers on

333 Mendeley
1 CiteULike
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Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
Published in
Epigenetics & Chromatin, July 2015
DOI 10.1186/s13072-015-0016-6
Pubmed ID

Achim Breiling, Frank Lyko


The chemical modification of DNA bases plays a key role in epigenetic gene regulation. While much attention has been focused on the classical epigenetic mark, 5-methylcytosine, the field garnered increased interest through the recent discovery of additional modifications. In this review, we focus on the epigenetic regulatory roles of DNA modifications in animals. We present the symmetric modification of 5-methylcytosine on CpG dinucleotide as a key feature, because it permits the inheritance of methylation patterns through DNA replication. However, the distribution patterns of cytosine methylation are not conserved in animals and independent molecular functions will likely be identified. Furthermore, the discovery of enzymes that catalyse the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine not only identified an active demethylation pathway, but also a candidate for a new epigenetic mark associated with activated transcription. Most recently, N6-methyladenine was described as an additional eukaryotic DNA modification with epigenetic regulatory potential. Interestingly, this modification is also present in genomes that lack canonical cytosine methylation patterns, suggesting independent functions. This newfound diversity of DNA modifications and their potential for combinatorial interactions indicates that the epigenetic DNA code is substantially more complex than previously thought.

Twitter Demographics

The data shown below were collected from the profiles of 32 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Germany 1 <1%
Moldova, Republic of 1 <1%
Italy 1 <1%
Switzerland 1 <1%
New Zealand 1 <1%
Belgium 1 <1%
Spain 1 <1%
United States 1 <1%
Other 1 <1%
Unknown 322 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 94 28%
Student > Master 51 15%
Student > Bachelor 50 15%
Researcher 36 11%
Student > Doctoral Student 27 8%
Other 34 10%
Unknown 41 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 108 32%
Agricultural and Biological Sciences 107 32%
Chemistry 24 7%
Neuroscience 10 3%
Medicine and Dentistry 10 3%
Other 23 7%
Unknown 51 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2015.
All research outputs
of 17,954,410 outputs
Outputs from Epigenetics & Chromatin
of 499 outputs
Outputs of similar age
of 242,225 outputs
Outputs of similar age from Epigenetics & Chromatin
of 1 outputs
Altmetric has tracked 17,954,410 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 499 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them