I think it is worth reviewing the recently emerging concept of "shielding of hematopoietic stem cells" now: 1. Knock-out of CD33 (https://t.co/RhP9tDiWIB) 2. Epitope editing of CD117 (https://t.co/rSCDRgRBNv), CD45 (https://t.co/4Z6e6nc8Ed) and CD123 (http
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@carlhjune @CasiratiG @Genovese_Lab As it is often the case in science, this work build on previous work that established the feasibility of combining CAR-T cell therapy with a gene edited hematopoietic stem cell transplant in which the targeted antigen ha
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🐁 study re: CD7.CAR-T that normally knock out normal T & NK cells. If you chase CAR-T with engineered CD7-KO HSCs, functional CD7-neg reconstitution occurs. Similar concept with CD33/AML: https://t.co/LAPq3XTAek Looking forward to world where every m
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@adamfeuerstein @sheridan_kate Links to 2 relevant papers; Sid' Mukherjee is first. Second is from Saar Gill et al https://t.co/AP9n3gkyCE https://t.co/Krt3FNqd9X https://t.co/BBuA7c0bXW