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Complement and macrophage crosstalk during process of angiogenesis in tumor progression

Overview of attention for article published in Journal of Biomedical Science, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#50 of 586)
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
8 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
92 Mendeley
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Title
Complement and macrophage crosstalk during process of angiogenesis in tumor progression
Published in
Journal of Biomedical Science, July 2015
DOI 10.1186/s12929-015-0151-1
Pubmed ID
Authors

M. Afzal Khan, A. M. Assiri, D. C. Broering

Abstract

The complement system, which contains some of the most potent pro-inflammatory mediators in the tissue including the anaphylatoxins C3a and C5a are the vital parts of innate immunity. Complement activation seems to play a more critical role in tumor development, but little attention has been given to the angiogenic balance of the activated complement mediators and macrophage polarization during tumor progression. The tumor growth mainly supported by the infiltration of M2- tumor-associated macrophages, and high levels of C3a and C5a, whereas M1-macrophages contribute to immune-mediated tumor suppression. Macrophages express a cognate receptors for both C3a and C5a on their cell surface, and specific binding of C3a and C5a affects the functional modulation and angiogenic properties. Activation of complement mediators induce angiogenesis, favors an immunosuppressive microenvironment, and activate cancer-associated signaling pathways to assist chronic inflammation. In this review manuscript, we highlighted the specific roles of complement activation and macrophage polarization during uncontrolled angiogenesis in tumor progression, and therefore blocking of complement mediators would be an alternative therapeutic option for treating cancer.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Malaysia 1 1%
Italy 1 1%
Unknown 89 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 21%
Researcher 16 17%
Student > Master 13 14%
Student > Bachelor 10 11%
Student > Doctoral Student 6 7%
Other 15 16%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 23%
Biochemistry, Genetics and Molecular Biology 21 23%
Medicine and Dentistry 20 22%
Immunology and Microbiology 6 7%
Unspecified 1 1%
Other 3 3%
Unknown 20 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2016.
All research outputs
#1,616,666
of 11,466,479 outputs
Outputs from Journal of Biomedical Science
#50
of 586 outputs
Outputs of similar age
#42,542
of 235,235 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 22 outputs
Altmetric has tracked 11,466,479 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 586 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,235 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.