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Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats

Overview of attention for article published in BMC Complementary Medicine and Therapies, July 2015
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Title
Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats
Published in
BMC Complementary Medicine and Therapies, July 2015
DOI 10.1186/s12906-015-0786-1
Pubmed ID
Authors

Woosuk Kim, Dae Won Kim, Dae Young Yoo, Hyo Young Jung, Jong Whi Kim, Dong-Woo Kim, Jung Hoon Choi, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang

Abstract

Dendropanax morbifera Léveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated the antioxidant effects of a leaf extract of Dendropanax morbifera Léveille in the hippocampus of mercury-exposed rats. Seven-week-old Sprague-Dawley rats received a daily intraperitoneal injection of 5 μg/kg dimethylmercury and/or oral Dendropanax morbifera Léveille leaf extract (100 mg/kg) for 4 weeks. Animals were sacrificed 2 h after the last dimethylmercury and/or leaf extract treatment. Mercury levels were measured in homogenates of hippocampal tissue, a brain region that is vulnerable to mercury toxicity. In addition, we measured reactive oxygen species production, lipid peroxidation levels, and antioxidant levels in these hippocampal homogenates. Treatment with Dendropanax morbifera Léveille leaf extract significantly reduced mercury levels in hippocampal homogenates and attenuated the dimethylmercury-induced increase in the production of reactive oxygen species and formation of malondialdehyde. In addition, this leaf extract treatment significantly reversed the dimethylmercury-induced reduction in the hippocampal activities of Cu, Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase. These results suggest that a leaf extract of Dendropanax morbifera Léveille had strong antioxidant effects in the hippocampus of mercury-exposed rats.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 25%
Student > Ph. D. Student 2 17%
Unspecified 1 8%
Student > Bachelor 1 8%
Researcher 1 8%
Other 1 8%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Biochemistry, Genetics and Molecular Biology 1 8%
Unspecified 1 8%
Materials Science 1 8%
Psychology 1 8%
Other 0 0%
Unknown 5 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2015.
All research outputs
#18,418,919
of 22,817,213 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,511
of 3,630 outputs
Outputs of similar age
#189,490
of 263,718 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#66
of 98 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,718 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.