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Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection

Overview of attention for article published in BMC Infectious Diseases, May 2018
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Title
Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection
Published in
BMC Infectious Diseases, May 2018
DOI 10.1186/s12879-018-3156-z
Pubmed ID
Authors

Dimitrios Sinapidis, Vassileios Kosmas, Vasileios Vittoros, Ioannis M. Koutelidakis, Aikaterini Pantazi, Aggelos Stefos, Konstantinos E. Katsaros, Karolina Akinosoglou, Magdalini Bristianou, Konstantinos Toutouzas, Michael Chrisofos, Evangelos J. Giamarellos-Bourboulis

Abstract

Development of sepsis is a process with significant variation among individuals. The precise elements of this variation need to be defined. This study was designed to define the way in which comorbidities contribute to sepsis development. Three thousand five hundred nine patients with acute pyelonephritis (AP), community-acquired pneumonia (CAP), intraabdominal infections (IAI) or primary bacteremia (BSI) and at least two signs of the systemic inflammatory response syndrome were analyzed. The study primary endpoint was to define how comorbidities as expressed in the Charlson's comorbidity index (CCI) and the underlying type of infection contribute to development of organ dysfunction. The precise comorbidities that mediate sepsis development and risk for death among 18 comorbidities recorded were the secondary study endpoints. CCI more than 2 had an odds ratio of 5.67 for sepsis progression in patients with IAI between significantly higher than AP and BSI. Forward logistic regression analysis indicated seven comorbidities that determine transition into sepsis in patients with AP, four comorbidities in CAP, six comorbidities in IAI and one in BSI. The odds ratio both for progression to sepsis and death with one comorbidity or with two and more comorbidities was greater than in the absence of comorbidities. The study described how different kinds of infection vary in the degree to which they lead to sepsis. The number of comorbidities that enhances the risk of sepsis and death varies depending on the underlying infections.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 40%
Other 2 20%
Professor 1 10%
Student > Postgraduate 1 10%
Professor > Associate Professor 1 10%
Other 1 10%
Readers by discipline Count As %
Unspecified 4 40%
Medicine and Dentistry 4 40%
Computer Science 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2018.
All research outputs
#9,970,252
of 13,034,624 outputs
Outputs from BMC Infectious Diseases
#3,089
of 4,852 outputs
Outputs of similar age
#187,752
of 271,406 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 1 outputs
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