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Planning and Analyzing Clinical Trials with Composite Endpoints

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Cover of 'Planning and Analyzing Clinical Trials with Composite Endpoints'

Table of Contents

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    Book Overview
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    Chapter 1 Definition and Rationale
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    Chapter 2 Challenges of Composite Endpoints
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    Chapter 3 Guideline View: Recommendations and Requirements
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    Chapter 4 Clinical Trial Examples
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    Chapter 5 The Single-Stage Design
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    Chapter 6 Group-Sequential and Adaptive Designs
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    Chapter 7 Related Software Code
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    Chapter 8 Correlation Between Test Statistics
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    Chapter 9 The Single-Stage Design
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    Chapter 10 Group-Sequential and Adaptive Designs
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    Chapter 11 Related Software Code
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    Chapter 12 Weighted Composite Binary Endpoint
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    Chapter 13 Weighted Composite Time-to-Event Endpoint
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    Chapter 14 Other Weighted Effect Measures
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    Chapter 15 Related Software Code
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    Chapter 16 Descriptive Analysis of the Components
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    Chapter 17 Supplementary Confirmatory Analyses of the Components
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    Chapter 18 Related Software Code
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    Chapter 19 Clinical Trial Examples with (Composite) Binary Endpoints
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    Chapter 20 Clinical Trial Examples with (Composite) Time-to-Event Endpoints
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