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14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders.

Overview of attention for article published in Scientific Reports, July 2015
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Title
14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders.
Published in
Scientific Reports, July 2015
DOI 10.1038/srep12434
Pubmed ID
Authors

Xu, Xiangjun, Jaehne, Emily J, Greenberg, Zarina, McCarthy, Peter, Saleh, Eiman, Parish, Clare L, Camera, Daria, Heng, Julian, Haas, Matilda, Baune, Bernhard T, Ratnayake, Udani, Buuse, Maarten van den, Lopez, Angel F, Ramshaw, Hayley S, Schwarz, Quenten, Xiangjun Xu, Emily J. Jaehne, Zarina Greenberg, Peter McCarthy, Eiman Saleh, Clare L. Parish, Daria Camera, Julian Heng, Matilda Haas, Bernhard T. Baune, Udani Ratnayake, Maarten van den Buuse, Angel F. Lopez, Hayley S. Ramshaw, Quenten Schwarz

Abstract

Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we recently found that 14-3-3ζ(-/-) mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play a significant role in disease pathogenesis we generated a new congenic strain in the BALB/c background to determine the impact of genetic interactions on the 14-3-3ζ(-/-) phenotype. In addition to replicating defects such as aberrant mossy fibre connectivity and impaired spatial memory, our analysis of 14-3-3ζ(-/-) BALB/c mice identified enlarged lateral ventricles, reduced synaptic density and ectopically positioned pyramidal neurons in all subfields of the hippocampus. In contrast to our previous analyses, 14-3-3ζ(-/-) BALB/c mice lacked locomotor hyperactivity that was underscored by normal levels of the dopamine transporter (DAT) and dopamine signalling. Taken together, our results demonstrate that dysfunction of 14-3-3ζ gives rise to many of the pathological hallmarks associated with the human condition. 14-3-3ζ-deficient BALB/c mice therefore provide a novel model to address the underlying biology of structural defects affecting the hippocampus and ventricle, and cognitive defects such as hippocampal-dependent learning and memory.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 20%
Student > Master 2 20%
Student > Ph. D. Student 2 20%
Researcher 2 20%
Student > Doctoral Student 1 10%
Other 1 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 60%
Arts and Humanities 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Medicine and Dentistry 1 10%
Engineering 1 10%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2015.
All research outputs
#6,990,919
of 8,074,808 outputs
Outputs from Scientific Reports
#27,896
of 32,939 outputs
Outputs of similar age
#191,007
of 229,231 outputs
Outputs of similar age from Scientific Reports
#1,393
of 1,639 outputs
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