Title |
Role of clinical bioinformatics in the development of network-based Biomarkers
|
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Published in |
Journal of Clinical Bioinformatics, October 2011
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DOI | 10.1186/2043-9113-1-28 |
Pubmed ID | |
Authors |
Xiangdong Wang |
Abstract |
Network biomarker as a new type of biomarkers with protein-protein interactions was initiated and investigated with the integration of knowledge on protein annotations, interaction, and signaling pathway. A number of methodologies and computational programs have been developed to integrate selected proteins into the knowledge-based networks via the combination of genomics, proteomics and bioinformatics. Alterations of network biomarkers can be monitored and evaluated at different stages and time points during the development of diseases, named dynamic network biomarkers. Dynamic network biomarkers should be furthermore correlated with clinical informatics, including patient complaints, history, therapies, clinical symptoms and signs, physician's examinations, biochemical analyses, imaging profiles, pathologies and other measurements. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Egypt | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 2% |
Spain | 1 | 2% |
United States | 1 | 2% |
Italy | 1 | 2% |
Unknown | 53 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 25% |
Student > Ph. D. Student | 10 | 18% |
Student > Master | 7 | 12% |
Student > Bachelor | 5 | 9% |
Other | 3 | 5% |
Other | 6 | 11% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 23% |
Agricultural and Biological Sciences | 11 | 19% |
Computer Science | 9 | 16% |
Medicine and Dentistry | 3 | 5% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 7% |
Unknown | 15 | 26% |