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Screening for primary aldosteronism in an argentinian population: a multicenter prospective study

Overview of attention for article published in Archives of Endocrinology and Metabolism, October 2015
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Title
Screening for primary aldosteronism in an argentinian population: a multicenter prospective study
Published in
Archives of Endocrinology and Metabolism, October 2015
DOI 10.1590/2359-3997000000075
Pubmed ID
Authors

Mariela Leal Reyna, Reynaldo M. Gómez, Susana N. Lupi, Susana H. Belli, Cecilia A. Fenili, Marcela S. Martínez, Gabriela F. Ruibal, María A Rossi, Raúl A Chervin, Dora Cornaló, Liliana N. Contreras, Liliana Costa, María T. Nofal, Sergio A. Damilano, Ester M. Pardes

Abstract

Objectives Primary aldosteronism (PA) is characterized by the autonomous overproduction of aldosterone. Its prevalence has increased since the use of the aldosterone (ALD)/plasma renin activity (PRA) ratio (ARR). The objective of this study is to determine ARR and ARC (ALD/plasma renin concentration ratio) cut-off values (COV) and their diagnostic concordance (DC%) in the screening for PA in an Argentinian population. Design multicenter prospective study. Subjects and methods We studied 353 subjects (104 controls and 249 hypertensive patients). Serum aldosterone, PRA and ARR were determined. In 220 randomly selected subjects, 160 hypertensive patients and 60 controls, plasma renin concentration (PRC) was simultaneously measured and ARC was determined. Results According to the 95th percentile of controls, we determined a COV of 36 for ARR and 2.39 for ARC, with ALD ≥ 15 ng/dL. In 31/249 hypertensive patients, ARR was ≥ 36. PA diagnosis was established in 8/31 patients (23/31 patients did not complete confirmatory tests). DC% between ARR and ARC was calculated. A significant correlation between ARR and ARC (r = 0.742; p < 0.0001) was found only with PRA > 0.3 ng/mL/h and PRC > 5 pg/mL. DC% for ARR and ARC above or below 36 and 2.39 was 79.1%, respectively. Conclusion This first Argentinian multicenter study determined a COV of 36 for ARR and 2.39 for ARC. Applying an ARR ≥ 36 in the hypertensive group, we confirmed PA in a higher percentage of patients than the previously reported one in our population. As for ARC, further studies are needed for its clinical application, since DC% is acceptable only for medium range renin values.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 20%
Researcher 3 15%
Student > Postgraduate 2 10%
Student > Ph. D. Student 2 10%
Professor 1 5%
Other 5 25%
Unknown 3 15%
Readers by discipline Count As %
Medicine and Dentistry 11 55%
Social Sciences 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Materials Science 1 5%
Other 0 0%
Unknown 4 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2016.
All research outputs
#13,928,563
of 15,793,291 outputs
Outputs from Archives of Endocrinology and Metabolism
#91
of 130 outputs
Outputs of similar age
#192,911
of 236,334 outputs
Outputs of similar age from Archives of Endocrinology and Metabolism
#3
of 4 outputs
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So far Altmetric has tracked 130 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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