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Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, July 2015
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Title
Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, July 2015
DOI 10.1186/s40409-015-0022-y
Pubmed ID
Authors

Márcia Marinho, Cilene Vidovix Táparo, Itamar S. Oliveira-Júnior, Silvia Helena Venturoli Perri, Tereza Cristina Cardoso

Abstract

This investigation aimed to evaluate the occurrence of some apoptotic features induced by Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi). The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed. Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2, 4 and 7 (p = 0.025; p < 0.05). Lung sections revealed caspase-3 labeled alveolar cells in 10 and 14 days post-infection was higher than observed at 7 days (p = 0.0497; p < 0.05). Liver sections demonstrated reactive cells at a highest level at 14 and 21 days post-infection when comparison to 2, 4, 7 and 10 days (p = 0.0069; p < 0.05). Our results suggest that infection of L. interrogans induce in kidney, liver and lung an activation of apoptosis mediated by caspase-3 dependent pathway in later phases of infectious process.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 25%
Student > Master 4 20%
Student > Bachelor 3 15%
Librarian 2 10%
Professor 2 10%
Other 1 5%
Unknown 3 15%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 4 20%
Agricultural and Biological Sciences 4 20%
Medicine and Dentistry 3 15%
Immunology and Microbiology 3 15%
Arts and Humanities 1 5%
Other 2 10%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2015.
All research outputs
#4,511,209
of 5,422,157 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#216
of 221 outputs
Outputs of similar age
#152,111
of 189,597 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#14
of 14 outputs
Altmetric has tracked 5,422,157 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 221 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.