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Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, July 2015
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2 tweeters

Citations

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4 Dimensions

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28 Mendeley
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Title
Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy
Published in
Memórias do Instituto Oswaldo Cruz, July 2015
DOI 10.1590/0074-02760140230
Pubmed ID
Authors

André Flores Braga, Daniela Ferraz Moretto, Patrícia Gigliotti, Mariela Peruchi, Fátima Regina Vilani-Moreno, Ana Paula Campanelli, Ana Carla Pereira Latini, Anand Iyer, Pranab Kumar Das, Vânia Nieto Brito de Souza

Abstract

Dendritic cells (DCs) play a pivotal role in the connection of innate and adaptive immunity of hosts to mycobacterial infection. Studies on the interaction of monocyte-derived DCs (MO-DCs) using Mycobacterium leprae in leprosy patients are rare. The present study demonstrated that the differentiation of MOs to DCs was similar in all forms of leprosy compared to normal healthy individuals. In vitro stimulation of immature MO-DCs with sonicated M. leprae induced variable degrees of DC maturation as determined by the increased expression of HLA-DR, CD40, CD80 and CD86, but not CD83, in all studied groups. The production of different cytokines by the MO-DCs appeared similar in all of the studied groups under similar conditions. However, the production of interleukin (IL)-12p70 by MO-DCs from lepromatous (LL) leprosy patients after in vitro stimulation with M. leprae was lower than tuberculoid leprosy patients and healthy individuals, even after CD40 ligation with CD40 ligand-transfected cells. The present cumulative findings suggest that the MO-DCs of LL patients are generally a weak producer of IL-12p70 despite the moderate activating properties of M. leprae. These results may explain the poor M. leprae-specific cell-mediated immunity in the LL type of leprosy.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 21%
Researcher 5 18%
Librarian 3 11%
Unspecified 2 7%
Student > Postgraduate 2 7%
Other 5 18%
Unknown 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 25%
Immunology and Microbiology 5 18%
Medicine and Dentistry 5 18%
Unspecified 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 4 14%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#7,544,820
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#565
of 862 outputs
Outputs of similar age
#114,734
of 234,704 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#3
of 7 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,704 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.