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Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator

Overview of attention for article published in Molecules, June 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
5 tweeters

Citations

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5 Dimensions

Readers on

mendeley
24 Mendeley
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Title
Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
Published in
Molecules, June 2018
DOI 10.3390/molecules23061385
Pubmed ID
Authors

Anabela Borges, Manuel Simões, Tamara Todorović, Nenad Filipović, Alfonso García-Sosa

Abstract

Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)₂) synthesized from (E)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-4-(p-tolyl)thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 21%
Researcher 3 13%
Student > Bachelor 3 13%
Student > Ph. D. Student 2 8%
Professor 1 4%
Other 4 17%
Unknown 6 25%
Readers by discipline Count As %
Chemistry 4 17%
Biochemistry, Genetics and Molecular Biology 4 17%
Agricultural and Biological Sciences 2 8%
Computer Science 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 5 21%
Unknown 7 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2018.
All research outputs
#3,863,398
of 13,087,494 outputs
Outputs from Molecules
#1,098
of 7,790 outputs
Outputs of similar age
#103,031
of 270,557 outputs
Outputs of similar age from Molecules
#41
of 376 outputs
Altmetric has tracked 13,087,494 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,790 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,557 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 376 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.