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The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates

Overview of attention for article published in Annals of General Psychiatry, June 2018
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Title
The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates
Published in
Annals of General Psychiatry, June 2018
DOI 10.1186/s12991-018-0192-4
Pubmed ID
Authors

Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Guan K. Tay

Abstract

Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations. This study is the first study to determine the allele frequency and the genetic association of the DRD2 rs1076560 SNP and OPRM1 rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE). A cross-sectional case-control cohort that consisted of 512 male subjects was studied. Two hundred and fifty patients with SUD receiving treatment at the UAE National Rehabilitation Center were compared to 262 controls with no prior history of mental health and SUD. DNA from each subject was extracted and genotyped using the TaqMan ® SNP genotyping assay. There were no significant associations observed for DRD2 rs1076560 SNP, OPRM1 rs1799971 SNP, and combined genotypes of both SNPs in the SUD group. Further research is required with refinements to the criteria of the clinical phenotypes. Genetic studies have to be expanded to include other variants of the gene, the interaction with other genes, and possible epigenetic relationships.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 10%
Professor 1 10%
Student > Ph. D. Student 1 10%
Professor > Associate Professor 1 10%
Lecturer 1 10%
Other 1 10%
Unknown 4 40%
Readers by discipline Count As %
Medicine and Dentistry 3 30%
Neuroscience 1 10%
Psychology 1 10%
Unknown 5 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2018.
All research outputs
#11,588,649
of 13,044,081 outputs
Outputs from Annals of General Psychiatry
#276
of 321 outputs
Outputs of similar age
#234,594
of 270,482 outputs
Outputs of similar age from Annals of General Psychiatry
#1
of 1 outputs
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