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Hypoxic metabolism in human hematopoietic stem cells

Overview of attention for article published in Cell & Bioscience, July 2015
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1 tweeter

Citations

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39 Mendeley
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Title
Hypoxic metabolism in human hematopoietic stem cells
Published in
Cell & Bioscience, July 2015
DOI 10.1186/s13578-015-0020-3
Pubmed ID
Authors

Fatih Kocabas, Li Xie, Jingjing Xie, Zhuo Yu, Ralph J. DeBerardinis, Wataru Kimura, SuWannee Thet, Ahmed F. Elshamy, Hesham Abouellail, Shalini Muralidhar, Xiaoye Liu, Chiqi Chen, Hesham A. Sadek, Cheng Cheng Zhang, Junke Zheng

Abstract

Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment, known as niche in the endosteal regions of the bone marrow. This stem cell niche with low oxygen tension requires HSCs to adopt a unique metabolic profile. We have recently demonstrated that mouse long-term hematopoietic stem cells (LT-HSCs) utilize glycolysis instead of mitochondrial oxidative phosphorylation as their main energy source. However, the metabolic phenotype of human hematopoietic progenitor and stem cells (HPSCs) remains unknown. We show that HPSCs have a similar metabolic phenotype, as shown by high rates of glycolysis, and low rates of oxygen consumption. Fractionation of human mobilized peripheral blood cells based on their metabolic footprint shows that cells with a low mitochondrial potential are highly enriched for HPSCs. Remarkably, low MP cells had much better repopulation ability as compared to high MP cells. Moreover, similar to their murine counterparts, we show that Hif-1α is upregulated in human HPSCs, where it is transcriptionally regulated by Meis1. Finally, we show that Meis1 and its cofactors Pbx1 and HoxA9 play an important role in transcriptional activation of Hif-1α in a cooperative manner. These findings highlight the unique metabolic properties of human HPSCs and the transcriptional network that regulates their metabolic phenotype.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Turkey 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 31%
Student > Master 7 18%
Professor 4 10%
Researcher 4 10%
Student > Doctoral Student 2 5%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 46%
Medicine and Dentistry 7 18%
Biochemistry, Genetics and Molecular Biology 6 15%
Engineering 2 5%
Neuroscience 1 3%
Other 0 0%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2015.
All research outputs
#4,511,209
of 5,422,157 outputs
Outputs from Cell & Bioscience
#137
of 157 outputs
Outputs of similar age
#152,111
of 189,597 outputs
Outputs of similar age from Cell & Bioscience
#9
of 10 outputs
Altmetric has tracked 5,422,157 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 157 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,597 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.