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Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors

Overview of attention for article published in Clinical Sarcoma Research, June 2018
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Title
Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors
Published in
Clinical Sarcoma Research, June 2018
DOI 10.1186/s13569-018-0096-8
Pubmed ID
Authors

Kristin Teiken, Mark Kuehnel, Jan Rehkaemper, Hans Kreipe, Florian Laenger, Kais Hussein, Danny Jonigk

Abstract

Post-transplant smooth muscle tumors (PTSMTs) are rare mesenchymal neoplasms which occur after solid organ or haematopoietic stem cell transplantation. PTSMT typically consist of Epstein-Barr-virus (EBV)+ smooth muscle-like cells and show an intermediate malignancy. Their main occurrences are visceral organs, especially the liver, but intracranial appearances are described and associated with a poor prognosis. EBV drives the growth of PTSMT; however, the underlying molecular mechanisms still remain unclear. Gene expression analysis of a set of morphologically similar tumors (leiomyomas, leiomyosarcomas, angioleiomyomas and endothelial haemangiomas) from patients without immunosuppression or EBV-association was performed. Our findings indicate that PTSMT's growth is driven by two factors of the wingless-type protein family: WNT6 and WNT10A. We are first to report that in PTSMTs, a non-canonical activation of WNT, independent of beta-catenin, drives tumor cell proliferation via MTOR/AKT1, MYC and Cyclin D2.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 29%
Other 1 14%
Student > Bachelor 1 14%
Student > Postgraduate 1 14%
Student > Doctoral Student 1 14%
Other 0 0%
Unknown 1 14%
Readers by discipline Count As %
Medicine and Dentistry 3 43%
Physics and Astronomy 1 14%
Neuroscience 1 14%
Immunology and Microbiology 1 14%
Unknown 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#11,588,541
of 13,043,953 outputs
Outputs from Clinical Sarcoma Research
#65
of 77 outputs
Outputs of similar age
#234,579
of 270,453 outputs
Outputs of similar age from Clinical Sarcoma Research
#2
of 2 outputs
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So far Altmetric has tracked 77 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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