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CO2 – Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, August 2015
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Title
CO2 – Intrinsic Product, Essential Substrate, and Regulatory Trigger of Microbial and Mammalian Production Processes
Published in
Frontiers in Bioengineering and Biotechnology, August 2015
DOI 10.3389/fbioe.2015.00108
Pubmed ID
Authors

Bastian Blombach, Ralf Takors

Abstract

Carbon dioxide formation mirrors the final carbon oxidation steps of aerobic metabolism in microbial and mammalian cells. As a consequence, [Formula: see text] dissociation equilibria arise in fermenters by the growing culture. Anaplerotic reactions make use of the abundant [Formula: see text] levels for refueling citric acid cycle demands and for enabling oxaloacetate-derived products. At the same time, CO2 is released manifold in metabolic reactions via decarboxylation activity. The levels of extracellular [Formula: see text] depend on cellular activities and physical constraints such as hydrostatic pressures, aeration, and the efficiency of mixing in large-scale bioreactors. Besides, local [Formula: see text] levels might also act as metabolic inhibitors or transcriptional effectors triggering regulatory events inside the cells. This review gives an overview about fundamental physicochemical properties of [Formula: see text] in microbial and mammalian cultures effecting cellular physiology, production processes, metabolic activity, and transcriptional regulation.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
South Africa 1 <1%
Unknown 111 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 19%
Student > Ph. D. Student 19 17%
Researcher 18 16%
Student > Bachelor 12 11%
Other 5 4%
Other 10 9%
Unknown 28 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 24%
Agricultural and Biological Sciences 18 16%
Chemical Engineering 10 9%
Engineering 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 14 12%
Unknown 32 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2015.
All research outputs
#18,420,033
of 22,818,766 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#3,394
of 6,538 outputs
Outputs of similar age
#189,802
of 263,982 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#33
of 49 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,538 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,982 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.