You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Spontaneous Human Adult Stem Cell Transformation
|
|---|---|
| Published in |
Cancer Research, April 2005
|
| DOI | 10.1158/0008-5472.can-04-4194 |
| Pubmed ID | |
| Authors |
Daniel Rubio, Javier Garcia-Castro, María C. Martín, Ricardo de la Fuente, Juan C. Cigudosa, Alison C. Lloyd, Antonio Bernad |
| Abstract |
Human adult stem cells are being evaluated widely for various therapeutic approaches. Several recent clinical trials have reported their safety, showing them to be highly resistant to transformation. The clear similarities between stem cell and cancer stem cell genetic programs are nonetheless the basis of a recent proposal that some cancer stem cells could derive from human adult stem cells. Here we show that although they can be managed safely during the standard ex vivo expansion period (6-8 weeks), human mesenchymal stem cells can undergo spontaneous transformation following long-term in vitro culture (4-5 months). This is the first report of spontaneous transformation of human adult stem cells, supporting the hypothesis of cancer stem cell origin. Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential. |
Twitter Demographics
The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 306 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| France | 4 | 1% |
| Austria | 1 | <1% |
| Sweden | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Iceland | 1 | <1% |
| Canada | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 288 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 64 | 21% |
| Student > Ph. D. Student | 57 | 19% |
| Student > Master | 43 | 14% |
| Student > Bachelor | 26 | 8% |
| Professor > Associate Professor | 15 | 5% |
| Other | 67 | 22% |
| Unknown | 34 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 103 | 34% |
| Medicine and Dentistry | 67 | 22% |
| Biochemistry, Genetics and Molecular Biology | 41 | 13% |
| Engineering | 16 | 5% |
| Neuroscience | 5 | 2% |
| Other | 28 | 9% |
| Unknown | 46 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2023.
All research outputs
#730,328
of 23,832,995 outputs
Outputs from Cancer Research
#488
of 18,521 outputs
Outputs of similar age
#813
of 59,307 outputs
Outputs of similar age from Cancer Research
#3
of 228 outputs
Altmetric has tracked 23,832,995 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,521 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 228 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.