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Spontaneous Human Adult Stem Cell Transformation

Overview of attention for article published in Cancer Research, April 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
blogs
5 blogs
policy
1 policy source
twitter
3 tweeters
patent
17 patents
peer_reviews
1 peer review site

Citations

dimensions_citation
905 Dimensions

Readers on

mendeley
300 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
Summary News Blogs Policy documents Twitter Patents Peer reviews Dimensions citations
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Title
Spontaneous Human Adult Stem Cell Transformation
Published in
Cancer Research, April 2005
DOI 10.1158/0008-5472.can-04-4194
Pubmed ID
15833829
Authors

Daniel Rubio, Javier Garcia-Castro, María C. Martín, Ricardo de la Fuente, Juan C. Cigudosa, Alison C. Lloyd, Antonio Bernad

Abstract

Human adult stem cells are being evaluated widely for various therapeutic approaches. Several recent clinical trials have reported their safety, showing them to be highly resistant to transformation. The clear similarities between stem cell and cancer stem cell genetic programs are nonetheless the basis of a recent proposal that some cancer stem cells could derive from human adult stem cells. Here we show that although they can be managed safely during the standard ex vivo expansion period (6-8 weeks), human mesenchymal stem cells can undergo spontaneous transformation following long-term in vitro culture (4-5 months). This is the first report of spontaneous transformation of human adult stem cells, supporting the hypothesis of cancer stem cell origin. Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
France 4 1%
Austria 1 <1%
Sweden 1 <1%
India 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Iceland 1 <1%
Canada 1 <1%
Other 2 <1%
Unknown 282 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 64 21%
Student > Ph. D. Student 57 19%
Student > Master 43 14%
Student > Bachelor 26 9%
Other 15 5%
Other 63 21%
Unknown 32 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 103 34%
Medicine and Dentistry 67 22%
Biochemistry, Genetics and Molecular Biology 41 14%
Engineering 16 5%
Neuroscience 5 2%
Other 25 8%
Unknown 43 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2023.
All research outputs
#730,328
of 23,832,995 outputs
Outputs from Cancer Research
#488
of 18,521 outputs
Outputs of similar age
#813
of 59,307 outputs
Outputs of similar age from Cancer Research
#3
of 228 outputs
Altmetric has tracked 23,832,995 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,521 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 59,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 228 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.

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