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Mendeley readers
Attention Score in Context
| Title |
A varying T cell subtype explains apparent tobacco smoking induced single CpG hypomethylation in whole blood
|
|---|---|
| Published in |
Clinical Epigenetics, August 2015
|
| DOI | 10.1186/s13148-015-0113-1 |
| Pubmed ID | |
| Authors |
Mario Bauer, Gunter Linsel, Beate Fink, Kirsten Offenberg, Anne Maria Hahn, Ulrich Sack, Heike Knaack, Markus Eszlinger, Gunda Herberth |
| Abstract |
Many recent epigenetic studies report that cigarette smoking reduces DNA methylation in whole blood at the single CpG site cg19859270 within the GPR15 gene. Within two independent cohorts, we confirmed the differentially expression of the GPR15 gene when smokers and non-smokers subjects are compared. By validating the GPR15 protein expression at the cellular level, we found that the observed decreased methylation at this site in white blood cells (WBC) of smokers is mainly caused by the high proportion of CD3+GPR15+ expressing T cells in peripheral blood. In current smokers, the percentage of GPR15+ cells among CD3+ T cells in peripheral blood is significantly higher (15.5 ± 7.2 %, mean ± standard deviation) compared to non-smokers (3.7 ± 1.6 %). Treatment of peripheral blood mononuclear cell (PBMC) cultures with aqueous cigarette smoke extract did not induce a higher proportion of this T cell subtype. Our results underline that DNA hypomethylation at cg19859270 site, observed in WBCs of smokers, did not arise by direct effect of tobacco smoking compounds on methylation of DNA but rather by the enrichment of a tobacco-smoking-induced lymphocyte population in the peripheral blood. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 25% |
| United States | 7 | 19% |
| France | 3 | 8% |
| Lebanon | 1 | 3% |
| Mongolia | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 14 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 67% |
| Scientists | 12 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Unknown | 141 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 12% |
| Student > Ph. D. Student | 10 | 7% |
| Student > Master | 5 | 3% |
| Student > Bachelor | 5 | 3% |
| Other | 4 | 3% |
| Other | 11 | 8% |
| Unknown | 91 | 64% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 12% |
| Medicine and Dentistry | 10 | 7% |
| Agricultural and Biological Sciences | 10 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Immunology and Microbiology | 3 | 2% |
| Other | 3 | 2% |
| Unknown | 91 | 64% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2024.
All research outputs
#1,635,898
of 25,476,463 outputs
Outputs from Clinical Epigenetics
#90
of 1,440 outputs
Outputs of similar age
#20,528
of 275,641 outputs
Outputs of similar age from Clinical Epigenetics
#6
of 42 outputs
Altmetric has tracked 25,476,463 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,440 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,641 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.