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Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche

Overview of attention for article published in Nature, June 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

news
9 news outlets
blogs
5 blogs
twitter
239 tweeters
facebook
2 Facebook pages

Citations

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13 Dimensions

Readers on

mendeley
117 Mendeley
Title
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
Published in
Nature, June 2018
DOI 10.1038/s41586-018-0213-0
Pubmed ID
Authors

Friedrich G. Kapp, Julie R. Perlin, Elliott J. Hagedorn, John M. Gansner, Daniel E. Schwarz, Lauren A. O’Connell, Nicholas S. Johnson, Chris Amemiya, David E. Fisher, Ute Wölfle, Eirini Trompouki, Charlotte M. Niemeyer, Wolfgang Driever, Leonard I. Zon

Abstract

Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour1,2. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by cmyb (also known as myb) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.

Twitter Demographics

The data shown below were collected from the profiles of 239 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 117 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 21%
Researcher 21 18%
Student > Master 18 15%
Student > Bachelor 13 11%
Student > Doctoral Student 8 7%
Other 15 13%
Unknown 17 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 47 40%
Agricultural and Biological Sciences 24 21%
Medicine and Dentistry 9 8%
Immunology and Microbiology 7 6%
Chemistry 4 3%
Other 8 7%
Unknown 18 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 231. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2019.
All research outputs
#63,868
of 14,564,429 outputs
Outputs from Nature
#6,486
of 72,653 outputs
Outputs of similar age
#2,751
of 276,801 outputs
Outputs of similar age from Nature
#221
of 887 outputs
Altmetric has tracked 14,564,429 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 72,653 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 80.9. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,801 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 887 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.