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Orally administered adenoviral-based vaccine induces respiratory mucosal memory and protection against RSV infection in cotton rats

Overview of attention for article published in Vaccine, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
7 news outlets
twitter
1 tweeter

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
28 Mendeley
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Title
Orally administered adenoviral-based vaccine induces respiratory mucosal memory and protection against RSV infection in cotton rats
Published in
Vaccine, July 2018
DOI 10.1016/j.vaccine.2018.05.112
Pubmed ID
Authors

Christina Joyce, Ciaran D. Scallan, Roberto Mateo, Robert B. Belshe, Sean N. Tucker, Anne C. Moore

Abstract

A vaccine against Respiratory Syncytial Virus (RSV) is a major unmet need to prevent the significant morbidity and mortality that it causes in society. In addition to efficacy, such a vaccine must not induce adverse events, as previously occurred with a formalin-inactivated vaccine (FI-RSV). In this study, the safety, immunogenicity and efficacy of a molecularly adjuvanted adenovirus serotype 5 based RSV vaccine encoding the fusion (F) protein (Ad-RSVF) is demonstrated in cotton rats. Protective immunity to RSV was induced by Ad-RSVF when administered by an oral route as well as by intranasal and intramuscular routes. Compared to FI-RSV, the Ad-RSVF vaccine induced significantly greater neutralizing antibody responses and protection against RSV infection. Significantly, oral or intranasal immunization each induced protective multi-functional effector and memory B cell responses in the respiratory tract. This study uniquely demonstrates the capacity of an orally administered adenovirus vaccine to induce protective immunity in the respiratory tract against RSV in a pre-clinical model and supports further clinical development of this oral Ad-RSVF vaccine strategy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 14%
Researcher 4 14%
Student > Ph. D. Student 3 11%
Student > Master 3 11%
Lecturer 2 7%
Other 3 11%
Unknown 9 32%
Readers by discipline Count As %
Immunology and Microbiology 5 18%
Biochemistry, Genetics and Molecular Biology 4 14%
Medicine and Dentistry 2 7%
Agricultural and Biological Sciences 1 4%
Nursing and Health Professions 1 4%
Other 4 14%
Unknown 11 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2018.
All research outputs
#379,596
of 15,555,267 outputs
Outputs from Vaccine
#266
of 12,616 outputs
Outputs of similar age
#13,254
of 279,453 outputs
Outputs of similar age from Vaccine
#7
of 196 outputs
Altmetric has tracked 15,555,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,616 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 196 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.