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Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

Overview of attention for article published in Radiation Oncology, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
120 Dimensions

Readers on

mendeley
127 Mendeley
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Title
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
Published in
Radiation Oncology, August 2015
DOI 10.1186/s13014-015-0462-0
Pubmed ID
Authors

Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken, Przemek M. Krawczyk

Abstract

The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia - treatment at elevated temperature - considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 2%
Poland 1 <1%
Netherlands 1 <1%
Belgium 1 <1%
Unknown 122 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 20%
Researcher 21 17%
Student > Master 20 16%
Student > Bachelor 17 13%
Student > Doctoral Student 8 6%
Other 22 17%
Unknown 13 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 22%
Medicine and Dentistry 24 19%
Agricultural and Biological Sciences 17 13%
Engineering 10 8%
Chemistry 6 5%
Other 19 15%
Unknown 23 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2015.
All research outputs
#2,375,891
of 6,615,543 outputs
Outputs from Radiation Oncology
#236
of 1,013 outputs
Outputs of similar age
#73,773
of 198,188 outputs
Outputs of similar age from Radiation Oncology
#20
of 65 outputs
Altmetric has tracked 6,615,543 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 1,013 research outputs from this source. They receive a mean Attention Score of 1.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,188 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.