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Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

Overview of attention for article published in Cell, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
18 news outlets
blogs
7 blogs
twitter
224 tweeters
facebook
1 Facebook page
wikipedia
2 Wikipedia pages
reddit
1 Redditor
video
2 video uploaders

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
138 Mendeley
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Title
Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration
Published in
Cell, June 2018
DOI 10.1016/j.cell.2018.05.006
Pubmed ID
Authors

An Zeng, Hua Li, Longhua Guo, Xin Gao, Sean McKinney, Yongfu Wang, Zulin Yu, Jungeun Park, Craig Semerad, Eric Ross, Li-Chun Cheng, Erin Davies, Kai Lei, Wei Wang, Anoja Perera, Kate Hall, Allison Peak, Andrew Box, Alejandro Sánchez Alvarado

Abstract

Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of markers to prospectively identify and isolate these adult PSCs has significantly hampered their characterization. We used single-cell RNA sequencing (scRNA-seq) and single-cell transplantation to address this long-standing issue. Large-scale scRNA-seq of sorted neoblasts unveiled a novel subtype of neoblast (Nb2) characterized by high levels of PIWI-1 mRNA and protein and marked by a conserved cell-surface protein-coding gene, tetraspanin 1 (tspan-1). tspan-1-positive cells survived sub-lethal irradiation, underwent clonal expansion to repopulate whole animals, and when purified with an anti-TSPAN-1 antibody, rescued the viability of lethally irradiated animals after single-cell transplantation. The first prospective isolation of an adult PSC bridges a conceptual dichotomy between functionally and molecularly defined neoblasts, shedding light on mechanisms governing in vivo pluripotency and a source of regeneration in animals. VIDEO ABSTRACT.

Twitter Demographics

The data shown below were collected from the profiles of 224 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 138 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 31%
Researcher 32 23%
Student > Bachelor 12 9%
Unspecified 12 9%
Student > Master 10 7%
Other 29 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 58 42%
Agricultural and Biological Sciences 48 35%
Unspecified 17 12%
Medicine and Dentistry 5 4%
Neuroscience 3 2%
Other 7 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 323. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2019.
All research outputs
#33,269
of 12,961,889 outputs
Outputs from Cell
#208
of 14,751 outputs
Outputs of similar age
#1,736
of 270,771 outputs
Outputs of similar age from Cell
#16
of 165 outputs
Altmetric has tracked 12,961,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,751 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,771 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.