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Delay in treatment intensification increases the risks of cardiovascular events in patients with type 2 diabetes

Overview of attention for article published in Cardiovascular Diabetology, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 904)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

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2 news outlets
twitter
35 tweeters
facebook
2 Facebook pages

Citations

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132 Dimensions

Readers on

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165 Mendeley
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Title
Delay in treatment intensification increases the risks of cardiovascular events in patients with type 2 diabetes
Published in
Cardiovascular Diabetology, August 2015
DOI 10.1186/s12933-015-0260-x
Pubmed ID
Authors

Sanjoy K Paul, Kerenaftali Klein, Brian L Thorsted, Michael L Wolden, Kamlesh Khunti

Abstract

The aim of the study was to evaluate the effect of delay in treatment intensification (IT; clinical inertia) in conjunction with glycaemic burden on the risk of macrovascular events (CVE) in type 2 diabetes (T2DM) patients. A retrospective cohort study was carried out using United Kingdom Clinical Practice Research Datalink, including T2DM patients diagnosed from 1990 with follow-up data available until 2012. In the cohort of 105,477 patients mean HbA1c was 8.1% (65 mmol/mol) at diagnosis, 11% had a history of cardiovascular disease, and 7.1% experienced at least one CVE during 5.3 years of median follow-up. In patients with HbA1c consistently above 7/7.5% (53/58 mmol/mol, n = 23,101/11,281) during 2 years post diagnosis, 26/22% never received any IT. Compared to patients with HbA1c <7% (<53 mmol/mol), in patients with HbA1c ≥7% (≥53 mmol/mol), a 1 year delay in receiving IT was associated with significantly increased risk of MI, stroke, HF and composite CVE by 67% (HR CI: 1.39, 2.01), 51% (HR CI: 1.25, 1.83), 64% (HR CI: 1.40, 1.91) and 62% (HR CI: 1.46, 1.80) respectively. One year delay in IT in interaction with HbA1c above 7.5% (58 mmol/mol) was also associated with similar increased risk of CVE. Among patients with newly diagnosed T2DM, 22% remained under poor glycaemic control over 2 years, and 26% never received IT. Delay in IT by 1 year in conjunction with poor glycaemic control significantly increased the risk of MI, HF, stroke and composite CVE.

Twitter Demographics

The data shown below were collected from the profiles of 35 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 2%
United Kingdom 1 <1%
Mexico 1 <1%
Unknown 160 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 15%
Student > Master 24 15%
Other 17 10%
Student > Bachelor 16 10%
Student > Ph. D. Student 14 8%
Other 43 26%
Unknown 27 16%
Readers by discipline Count As %
Medicine and Dentistry 75 45%
Nursing and Health Professions 12 7%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Biochemistry, Genetics and Molecular Biology 5 3%
Economics, Econometrics and Finance 5 3%
Other 18 11%
Unknown 41 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2018.
All research outputs
#563,047
of 15,922,938 outputs
Outputs from Cardiovascular Diabetology
#17
of 904 outputs
Outputs of similar age
#10,372
of 236,968 outputs
Outputs of similar age from Cardiovascular Diabetology
#1
of 1 outputs
Altmetric has tracked 15,922,938 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 904 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them