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Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats

Overview of attention for article published in Anais da Academia Brasileira de Ciências, August 2015
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Title
Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats
Published in
Anais da Academia Brasileira de Ciências, August 2015
DOI 10.1590/0001-3765201520140638
Pubmed ID
Authors

BRENA P. TEODORAK, GABRIELA K. FERREIRA, GISELLI SCAINI, LETÍCIA B. WESSLER, ALEXANDRA S. HEYLMANN, PEDRO DEROZA, SAMIRA S. VALVASSORI, ALEXANDRA I. ZUGNO, JOÃO QUEVEDO, EMILIO L. STRECK

Abstract

Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by increasing dopamine levels in the synaptic cleft. Considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats. Young male Wistar rats received a single injection of fenproporex (6.25, 12.5 or 25mg/kg i.p.) or vehicle (2% Tween 80). Two hours after the injection, the rats were killed by decapitation and the brain was removed for evaluation of acetylcholinesterase activity. Results showed that fenproporex administration increased acetylcholinesterase activity in the hippocampus and posterior cortex, whereas in the prefrontal cortex, striatum and cerebellum the enzyme activity was not altered. In conclusion, in the present study we demonstrated that acute administration of fenproporex exerts an effect in the cholinergic system causing an increase in the activity of acetylcholinesterase in a dose-dependent manner in the hippocampus and posterior cortex. Thus, we suggest that the imbalance in cholinergic homeostasis could be considered as an important pathophysiological mechanism underlying the brain damage observed in patients who use amphetamines such as fenproporex.

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Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 16%
Researcher 4 13%
Student > Ph. D. Student 4 13%
Student > Bachelor 3 10%
Professor 3 10%
Other 7 23%
Unknown 5 16%
Readers by discipline Count As %
Medicine and Dentistry 4 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Biochemistry, Genetics and Molecular Biology 3 10%
Neuroscience 3 10%
Agricultural and Biological Sciences 2 6%
Other 8 26%
Unknown 8 26%