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Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke

Overview of attention for article published in Nature Medicine, June 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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10 news outlets
blogs
1 blog
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30 X users
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1 patent
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2 Facebook pages

Citations

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95 Dimensions

Readers on

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170 Mendeley
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Title
Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke
Published in
Nature Medicine, June 2018
DOI 10.1038/s41591-018-0058-y
Pubmed ID
Authors

Dhakshin S. Ramanathan, Ling Guo, Tanuj Gulati, Gray Davidson, April K. Hishinuma, Seok-Joon Won, Robert T. Knight, Edward F. Chang, Raymond A. Swanson, Karunesh Ganguly

Abstract

Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 170 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 24%
Researcher 32 19%
Student > Master 19 11%
Student > Bachelor 12 7%
Student > Doctoral Student 12 7%
Other 19 11%
Unknown 35 21%
Readers by discipline Count As %
Neuroscience 57 34%
Medicine and Dentistry 19 11%
Engineering 15 9%
Agricultural and Biological Sciences 9 5%
Biochemistry, Genetics and Molecular Biology 6 4%
Other 19 11%
Unknown 45 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 95. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2022.
All research outputs
#449,170
of 25,542,788 outputs
Outputs from Nature Medicine
#1,513
of 9,374 outputs
Outputs of similar age
#9,740
of 342,117 outputs
Outputs of similar age from Nature Medicine
#44
of 118 outputs
Altmetric has tracked 25,542,788 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,374 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.