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Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria

Overview of attention for article published in Malaria Journal, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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3 tweeters
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1 Facebook page

Citations

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8 Dimensions

Readers on

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32 Mendeley
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Title
Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria
Published in
Malaria Journal, August 2015
DOI 10.1186/s12936-015-0832-y
Pubmed ID
Authors

Cynthia H Val, Fátima Brant, Aline S Miranda, Flávia G Rodrigues, Bruno C L Oliveira, Elândia A Santos, Diego R R Assis, Lísia Esper, Bruno C Silva, Milene A Rachid, Herbert B Tanowitz, Antônio L Teixeira, Mauro M Teixeira, Wiliam C B Régis, Fabiana S Machado

Abstract

Cerebral malaria (CM) is debilitating and sometimes fatal. Disease severity has been associated with poor treatment access, therapeutic complexity and drug resistance and, thus, alternative therapies are increasingly necessary. In this study, the effect of the administration of Agaricus blazei, a mushroom of Brazilian origin in a model of CM caused by Plasmodium berghei, strain ANKA, was investigated in mice. C57BL/6 mice were pre-treated with aqueous extract or fractions of A. blazei, or chloroquine, infected with P. berghei ANKA and then followed by daily administration of A. blazei or chloroquine. Parasitaemia, body weight, survival and clinical signs of the disease were evaluated periodically. The concentration of pro-and anti-inflammatory cytokines, histopathology and in vitro analyses were performed. Mice treated with A. blazei aqueous extract or fraction C, that shows antioxidant activity, displayed lower parasitaemia, increased survival, reduced weight loss and protection against the development of CM. The administration of A. blazei resulted in reduced levels of TNF, IL-1β and IL-6 production when compared to untreated P. berghei-infected mice. Agaricus blazei (aqueous extract or fraction C) treated infected mice displayed reduction of brain lesions. Although chloroquine treatment reduced parasitaemia, there was increased production of proinflammatory cytokines and damage in the CNS not observed with A. blazei treatment. Moreover, the in vitro pretreatment of infected erythrocytes followed by in vivo infection resulted in lower parasitaemia, increased survival, and little evidence of clinical signs of disease. This study strongly suggests that the administration of A. blazei (aqueous extract or fraction C) was effective in improving the consequences of CM in mice and may provide novel therapeutic strategies.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 28%
Student > Bachelor 5 16%
Student > Ph. D. Student 3 9%
Student > Master 2 6%
Professor > Associate Professor 2 6%
Other 6 19%
Unknown 5 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 22%
Biochemistry, Genetics and Molecular Biology 6 19%
Medicine and Dentistry 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Nursing and Health Professions 2 6%
Other 5 16%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2017.
All research outputs
#8,807,077
of 16,083,353 outputs
Outputs from Malaria Journal
#2,728
of 4,534 outputs
Outputs of similar age
#97,710
of 237,387 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 16,083,353 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,534 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,387 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them