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Mesenchymal stem cells in osteotomy repair after tibial tuberosity advancement in dogs with cranial cruciate ligament injury

Overview of attention for article published in Journal of Experimental Orthopaedics, June 2018
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Title
Mesenchymal stem cells in osteotomy repair after tibial tuberosity advancement in dogs with cranial cruciate ligament injury
Published in
Journal of Experimental Orthopaedics, June 2018
DOI 10.1186/s40634-018-0130-z
Pubmed ID
Authors

Clarissa Rocha dos Santos, Richard da Rocha Filgueiras, Patrícia Furtado Malard, Andre Rodrigues da Cunha Barreto-Vianna, Kaique Nogueira, Carolina da Silva Leite, Eduardo Maurício Mendes de Lima

Abstract

The cranial cruciate ligament rupture (CCLR) is the most commonly encountered orthopedic condition in dogs. Among the various techniques to treat this condition, tibial tuberosity advancement (TTA) has been used to obtain rapid recovery of the affected knee. The objective of this study was to evaluate the viability of the use of mesenchymal stem cells (MSC) implanted in the osteotomy site obtained by TTA in nine dogs diagnosed with CCLR. The MSC were isolated from the adipose tissue of the dogs and cultured for eight days, the animals were divided into two groups. Animals from the treated group (GT) received cell transport medium containing about 1.5 millions MSC, and the animals from the control group (GC) received only the cell transport medium. The study was performed in a double-blind manner using radiographs acquired on days 15, 30, 60 and 120 after the procedure. Evaluations of the density of the trabecular bone were performed using image analysis software. The results were subjected to descriptive statistical analysis, followed by the normality test, Chi-square test, Mann-Whitney test and Tukey's multiple comparison test for p ≤ 0.05. After 30 days of the procedure, the animals of the GT presented an ossification mean 36.45% greater (p ≤ 0.033) than the GC, and there were no statistical differences for the other periods. Despite the total bone ossification within the expected period, there was no minimization of the estimated recovery time with the application of MSC, and inflammatory factors should be considered for reassessment of the therapeutic intervention time.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 18%
Student > Ph. D. Student 3 14%
Student > Bachelor 3 14%
Researcher 2 9%
Student > Doctoral Student 2 9%
Other 1 5%
Unknown 7 32%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 7 32%
Medicine and Dentistry 5 23%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Engineering 1 5%
Other 0 0%
Unknown 7 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2018.
All research outputs
#20,522,137
of 23,090,520 outputs
Outputs from Journal of Experimental Orthopaedics
#310
of 338 outputs
Outputs of similar age
#288,117
of 328,569 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#8
of 10 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 338 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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