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Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma

Overview of attention for article published in Arquivos Brasileiros de Cardiologia, January 2018
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Title
Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma
Published in
Arquivos Brasileiros de Cardiologia, January 2018
DOI 10.5935/abc.20180052
Pubmed ID
Authors

Camilla Rayane De-Paula, Giselle Santos Magalhães, Nulma Souto Jentzsch, Camila Figueredo Botelho, Cleonice de Carvalho Coelho Mota, Tatiane Moisés Murça, Lidiana Fatima Correa Ramalho, Timothy C. Tan, Carolina Andrade Braganca Capuruço, Maria da Gloria Rodrigues-Machado

Abstract

Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls. Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI). Although pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E', p = 0.0047) and lower E' to late (E'/A', p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E' compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E'/A' ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups. Changes in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 17%
Other 5 14%
Student > Master 3 9%
Student > Ph. D. Student 2 6%
Student > Doctoral Student 2 6%
Other 5 14%
Unknown 12 34%
Readers by discipline Count As %
Medicine and Dentistry 7 20%
Sports and Recreations 3 9%
Nursing and Health Professions 2 6%
Psychology 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 4 11%
Unknown 16 46%