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Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis

Overview of attention for article published in Arthritis Research & Therapy, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

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2 news outlets
twitter
15 tweeters
facebook
1 Facebook page

Citations

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156 Dimensions

Readers on

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134 Mendeley
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Title
Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis
Published in
Arthritis Research & Therapy, August 2015
DOI 10.1186/s13075-015-0728-9
Pubmed ID
Authors

Teresa A. Simon, Adam Thompson, Kunal K. Gandhi, Marc C. Hochberg, Samy Suissa

Abstract

Patients with rheumatoid arthritis (RA) are at an increased risk of malignancies compared with the general population. This has raised concerns regarding these patients, particularly with the widespread use of immunomodulating therapies, including biologic disease-modifying antirheumatic drugs (DMARDs). We performed a systematic literature review and analysis to quantify the incidence of malignancies in patients with RA and the general population to update previously published data. A literature search was conducted that was consistent with and similar to that in a meta-analysis published in 2008. MEDLINE, BIOSIS Previews, Embase, Derwent Drug File and SciSearch databases were searched using specified search terms. Predefined inclusion criteria identified the relevant observational studies published between 2008 and 2014 that provided estimates of relative risk of malignancy in patients with RA compared with the general population. Risk data on overall malignancy and site-specific malignancies (lymphoma, melanoma and lung, colorectal, breast, cervical and prostate cancer) were extracted. The standardized incidence ratios (SIRs; a measure of risk) relative to the general population were evaluated and compared with published rates. A total of nine publications met the inclusion criteria. Seven of these reported SIRs for overall malignancy; eight for lymphoma, melanoma, and lung, colorectal and breast cancer; seven for prostate cancer; and four for cervical cancer. Compared with those in the general population, the SIR estimates for patients with RA suggest a modest increased risk in overall malignancy, as previously observed. Patients with RA continued to show an increased risk of lymphoma and lung cancer compared with the general population. Overall, SIR estimates for colorectal and breast cancers continued to show a decrease in risk, whereas cervical cancer, prostate cancer and melanoma appeared to show no consistent trend in risk among patients with RA compared with the general population. The additional data evaluated here are consistent with previously reported data. Patients with RA are at an increased risk of lung and lymphoma malignancies compared with the general population. Quantifying differences in malignancy rates between non-biologic and biologic DMARD-treated patients with RA may further highlight which malignancies may be related to treatment rather than to the underlying disease.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Greece 1 <1%
Italy 1 <1%
Unknown 131 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 16%
Researcher 19 14%
Student > Doctoral Student 18 13%
Student > Postgraduate 14 10%
Student > Master 10 7%
Other 30 22%
Unknown 21 16%
Readers by discipline Count As %
Medicine and Dentistry 66 49%
Agricultural and Biological Sciences 8 6%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Biochemistry, Genetics and Molecular Biology 7 5%
Immunology and Microbiology 4 3%
Other 10 7%
Unknown 32 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2018.
All research outputs
#605,704
of 13,260,771 outputs
Outputs from Arthritis Research & Therapy
#76
of 2,161 outputs
Outputs of similar age
#14,433
of 234,155 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 1 outputs
Altmetric has tracked 13,260,771 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,161 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,155 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them