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Elimination of Plasmodium falciparum in an area of multi-drug resistance

Overview of attention for article published in Malaria Journal, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

twitter
39 tweeters
peer_reviews
1 peer review site
reddit
1 Redditor

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
98 Mendeley
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Title
Elimination of Plasmodium falciparum in an area of multi-drug resistance
Published in
Malaria Journal, August 2015
DOI 10.1186/s12936-015-0838-5
Pubmed ID
Authors

Khin Maung Lwin, Mallika Imwong, Preyanan Suangkanarat, Atthanee Jeeyapant, Benchawan Vihokhern, Klanarong Wongsaen, Georges Snounou, Lilly Keereecharoen, Nicholas J White, Francois Nosten

Abstract

Resistance to the artemisinin derivatives in Plasmodium falciparum has emerged in Cambodia and is now spreading throughout South-East Asia. The rapid elimination of P. falciparum seems to be the only viable option to avoid a public health disaster but this is difficult because even in low transmission settings many residents have asymptomatic parasitaemias. In response to a large number of malaria cases reported in three remote villages on the Thai-Myanmar border where malaria is endemic and the disease is seasonal, surveys were conducted using an ultra-sensitive qPCR assay (LOD 22 parasites per mL). In one of the villages where it was feasible, mass anti-malarial drug administration was proposed to the population as a potential solution, and this was adopted. In the three villages 204/356 (57.3 %), 212/385 (55.1 %) and 195/286 (68.2 %) of the resident populations were positive by qPCR (approximately one-third P. falciparum and two-thirds P. vivax). Of those positive for P. falciparum 62 % carried single point mutations in the P. falciparum kelch protein (a marker of artemisinin resistance). In one of the villages 217 of 674 inhabitants received at least one dose of dihydroartemisinin-piperaquine chemoprevention in June 2012, 155 (71.4 %) received two consecutive months, and 98 (45.2 %) received three treatment doses. The chemoprevention was generally well tolerated. The sub-microscopic reservoir of P. falciparum malaria was eliminated during the six-month follow-up period (prevalence fell from 7 to 0 %); P. vivax malaria persisted (prevalence fell from 35 to 8 %). From June to October 2012 (rainy season) the number of clinical episodes of P. falciparum was six times lower (46), than during the same period in the previous year (290). Mass drug administration with dihydroartemisinin-piperaquine may be an effective strategy to eliminate P. falciparum rapidly where multi-drug resistance is present.

Twitter Demographics

The data shown below were collected from the profiles of 39 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Vietnam 1 1%
Kenya 1 1%
United Kingdom 1 1%
Thailand 1 1%
United States 1 1%
Unknown 91 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 34%
Student > Master 16 16%
Student > Ph. D. Student 9 9%
Student > Bachelor 8 8%
Other 7 7%
Other 17 17%
Unknown 8 8%
Readers by discipline Count As %
Medicine and Dentistry 31 32%
Agricultural and Biological Sciences 22 22%
Biochemistry, Genetics and Molecular Biology 10 10%
Social Sciences 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 14 14%
Unknown 11 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2016.
All research outputs
#722,288
of 14,363,802 outputs
Outputs from Malaria Journal
#120
of 4,141 outputs
Outputs of similar age
#15,392
of 235,859 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 14,363,802 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,141 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,859 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them