| Chapter title |
RNA Degradation in Neurodegenerative Disease
|
|---|---|
| Chapter number | 5 |
| Book title |
RNA Metabolism in Neurodegenerative Diseases
|
| Published in |
Advances in neurobiology, January 2018
|
| DOI | 10.1007/978-3-319-89689-2_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-989688-5, 978-3-31-989689-2
|
| Authors |
Kaitlin Weskamp, Sami J. Barmada, Weskamp, Kaitlin, Barmada, Sami J. |
| Abstract |
Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing physiological conditions. Tight regulation of RNA abundance through both transcription and degradation determines the amount, timing, and location of protein translation. This balance is of particular importance in neurons, which are among the most metabolically active and morphologically complex cells in the body. As a result, any disruptions in RNA degradation can have dramatic consequences for neuronal health. In this chapter, we will first discuss mechanisms of RNA stabilization and decay. We will then explore how the disruption of these pathways can lead to neurodegenerative disease. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 31% |
| Student > Master | 8 | 16% |
| Student > Doctoral Student | 4 | 8% |
| Researcher | 4 | 8% |
| Other | 4 | 8% |
| Other | 5 | 10% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 39% |
| Agricultural and Biological Sciences | 8 | 16% |
| Neuroscience | 4 | 8% |
| Business, Management and Accounting | 2 | 4% |
| Medicine and Dentistry | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |