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HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users

Overview of attention for article published in AIDS Research and Therapy, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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1 news outlet
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4 X users

Citations

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9 Dimensions

Readers on

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57 Mendeley
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Title
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users
Published in
AIDS Research and Therapy, August 2015
DOI 10.1186/s12981-015-0070-y
Pubmed ID
Authors

Valentine Budambula, Francis O. Musumba, Mark K. Webale, Titus M. Kahiga, Francisca Ongecha-Owuor, James N. Kiarie, George A. Sowayi, Aabid A. Ahmed, Collins Ouma, Tom Were

Abstract

Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations and their association with viral load and CD4+ T cell counts in HIV-1 infected IDUs (ART-naive, n = 32; and -experienced, n = 47) and non-drug users (ART-naive, n = 21; and -experienced, n = 32) naive for PI treatment from coastal Kenya. Only IDUs harboured major PI resistance mutations consisting of L90M, M46I and D30 N among 3 (6.4 %) ART-experienced and 1 (3.1 %) -naive individuals. Minor PI mutations including A71T, G48E, G48R, I13V, K20I, K20R, L10I, L10V, L33F, L63P, T74S, V11I, and V32L were detected among the ART-experienced (36.2 vs. 46.9 %) and -naive (43.8 vs. 66.7 %) IDUs and non-drug users, respectively. All the four IDUs possessing major mutations had high viral load while three presented with CD4+ T cell counts of <500 cells/ml. Among the ART-naive non-drug users, CD4+ T cell counts were significantly lower in carriers of minor mutations compared to non-carriers (P < 0.05). Transmitted drug resistance may occur in IDUs underscoring the need for genotyping resistance before initiating PI treatment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Belgium 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 25%
Student > Ph. D. Student 8 14%
Student > Postgraduate 6 11%
Student > Doctoral Student 5 9%
Researcher 5 9%
Other 9 16%
Unknown 10 18%
Readers by discipline Count As %
Immunology and Microbiology 9 16%
Biochemistry, Genetics and Molecular Biology 8 14%
Medicine and Dentistry 8 14%
Agricultural and Biological Sciences 6 11%
Mathematics 2 4%
Other 11 19%
Unknown 13 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2015.
All research outputs
#2,775,137
of 22,824,164 outputs
Outputs from AIDS Research and Therapy
#54
of 551 outputs
Outputs of similar age
#37,344
of 263,344 outputs
Outputs of similar age from AIDS Research and Therapy
#3
of 10 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 551 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.