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Altered birefringence of peripapillary retinal nerve fiber layer in multiple sclerosis measured by polarization sensitive optical coherence tomography

Overview of attention for article published in Eye and Vision, June 2018
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  • Among the highest-scoring outputs from this source (#32 of 214)
  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

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5 tweeters

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Title
Altered birefringence of peripapillary retinal nerve fiber layer in multiple sclerosis measured by polarization sensitive optical coherence tomography
Published in
Eye and Vision, June 2018
DOI 10.1186/s40662-018-0108-z
Pubmed ID
Authors

Hong Jiang, Wan Chen, Silvia Delgado, Yi Liu, Ying Lin, Jianhua Wang

Abstract

The retina has been used to study the pathophysiology of multiple sclerosis (MS). Peripapillary retinal nerve fiber layer (pRNFL) thinning has been suggested as an ocular biomarker of neurodegeneration in MS. The goal of this project was to determine the birefringence of the pRNFL by measuring the fiber birefringence using polarization sensitive optical coherence tomography (PS-OCT). Sixty-six MS patients without history of optic neuritis (age: 39.9 ± 11.0 yrs. old, 53 females and 13 males) and 66 age- and gender-matched normal controls (age: 40.7 ± 11.4 yrs. old) were recruited. Custom built PS-OCT was used to measure phase retardation per unit depth (PR/UD, proportional to the birefringence) and pRNFL thickness in each quadrant of the pRNFL. In addition, clinical manifestation was used to correlate with the pRNFL birefringence. The pRNFL was thinner in the temporal and inferior quadrants in MS patients compared with normal controls (P < 0.05). The PR/UD of the pRNFL was significantly decreased in MS patients (P < 0.05) in all quadrants except for the nasal quadrant. In both groups, the PR/UD from all four quadrants was not related to the averaged pRNFL thickness (P > 0.05). In MS patients, the PR/UD was not related to the expanded disability status scale (EDSS) nor disease duration (r ranged from - 0.17 to 0.02, P > 0.05). This is the first study using PS-OCT to study the pRNFL birefringence in MS patients. Decreased birefringence of the pRNFL may indicate microtubule abnormality, and could be a potential biomarker for detecting early neurodegeneration in MS.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 19%
Student > Doctoral Student 2 13%
Unspecified 2 13%
Student > Master 2 13%
Lecturer 1 6%
Other 4 25%
Unknown 2 13%
Readers by discipline Count As %
Neuroscience 6 38%
Engineering 3 19%
Unspecified 2 13%
Medicine and Dentistry 1 6%
Chemistry 1 6%
Other 0 0%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
All research outputs
#6,646,694
of 21,446,675 outputs
Outputs from Eye and Vision
#32
of 214 outputs
Outputs of similar age
#111,209
of 296,248 outputs
Outputs of similar age from Eye and Vision
#1
of 1 outputs
Altmetric has tracked 21,446,675 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 214 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them