Casandra Panea, Adam M. Farkas, Yoshiyuki Goto, Shahla Abdollahi-Roodsaz, Carolyn Lee, Balázs Koscsó, Kavitha Gowda, Tobias M. Hohl, Milena Bogunovic, Ivaylo I. Ivanov
Abstract
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103(+) DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2016.
All research outputs
#8,504,635
of 26,184,649 outputs
Outputs from Cell Reports
#10,588
of 13,470 outputs
Outputs of similar age
#90,787
of 277,667 outputs
Outputs of similar age from Cell Reports
#153
of 204 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
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