You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
RNAseq analysis of hippocampal microglia after kainic acid-induced seizures
|
|---|---|
| Published in |
Molecular Brain, June 2018
|
| DOI | 10.1186/s13041-018-0376-5 |
| Pubmed ID | |
| Authors |
Dale B. Bosco, Jiaying Zheng, Zhiyan Xu, Jiyun Peng, Ukpong B. Eyo, Ke Tang, Cheng Yan, Jun Huang, Lijie Feng, Gongxiong Wu, Jason R. Richardson, Hui Wang, Long-Jun Wu |
| Abstract |
Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq analysis upon microglia isolated from the hippocampus to determine expression pattern alterations following kainic acid induced seizure. We determined that microglia undergo dramatic changes to their expression patterns, particularly with regard to mitochondrial activity and metabolism. We also observed that microglia initiate immunological activity, specifically increasing interferon beta responsiveness. Our results provide novel insights into microglia transcriptional regulation following acute seizures and suggest potential therapeutic targets specifically in microglia for the treatment of seizures and epilepsy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 23% |
| Researcher | 8 | 12% |
| Student > Master | 6 | 9% |
| Student > Doctoral Student | 5 | 8% |
| Student > Bachelor | 4 | 6% |
| Other | 11 | 17% |
| Unknown | 17 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 33% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Immunology and Microbiology | 4 | 6% |
| Agricultural and Biological Sciences | 3 | 5% |
| Business, Management and Accounting | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 20 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2018.
All research outputs
#18,640,437
of 23,092,602 outputs
Outputs from Molecular Brain
#877
of 1,127 outputs
Outputs of similar age
#253,012
of 328,081 outputs
Outputs of similar age from Molecular Brain
#16
of 19 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,127 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,081 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.