↓ Skip to main content

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Overview of attention for article published in Biotechnology Advances, August 2015
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 904)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
2 blogs
twitter
10229 tweeters
peer_reviews
1 peer review site
facebook
11 Facebook pages
wikipedia
10 Wikipedia pages
googleplus
488 Google+ users
reddit
1 Redditor

Readers on

mendeley
730 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Published in
Biotechnology Advances, August 2015
DOI 10.1016/j.biotechadv.2015.08.001
Pubmed ID
Authors

Atanasov, Atanas G, Waltenberger, Birgit, Pferschy-Wenzig, Eva-Maria, Linder, Thomas, Wawrosch, Christoph, Uhrin, Pavel, Temml, Veronika, Wang, Limei, Schwaiger, Stefan, Heiss, Elke H, Rollinger, Judith M, Schuster, Daniela, Breuss, Johannes M, Bochkov, Valery, Mihovilovic, Marko D, Kopp, Brigitte, Bauer, Rudolf, Dirsch, Verena M, Stuppner, Hermann, Atanas G. Atanasov, Birgit Waltenberger, Eva-Maria Pferschy-Wenzig, Thomas Linder, Christoph Wawrosch, Pavel Uhrin, Veronika Temml, Limei Wang, Stefan Schwaiger, Elke H. Heiss, Judith M. Rollinger, Daniela Schuster, Johannes M. Breuss, Valery Bochkov, Marko D. Mihovilovic, Brigitte Kopp, Rudolf Bauer, Verena M. Dirsch, Hermann Stuppner, Atanas G Atanasov, Elke H Heiss, Judith M Rollinger, Johannes M Breuss, Marko D Mihovilovic, Verena M Dirsch, Atanasov, Atanas G., Heiss, Elke H., Bochkov, Valery N., Mihovilovic, Marko D., Dirsch, Verena M.

Abstract

Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to produce and resupply, and demonstrate good compatibility with established high throughput screening (HTS) platforms. However, at the same time there has been a declining trend in the number of new drugs reaching the market, raising renewed scientific interest in drug discovery from natural sources, despite of its known challenges. In this survey, a brief outline of historical development is provided together with a comprehensive overview of used approaches and recent developments relevant to plant-derived natural product drug discovery. Associated challenges and major strengths of natural product-based drug discovery are critically discussed. A snapshot of the advanced plant-derived natural products that are currently in actively recruiting clinical trials is also presented. Importantly, the transition of a natural compound from a "screening hit" through a "drug lead" to a "marketed drug" is associated with increasingly challenging demands for compound amount, which often cannot be met by re-isolation from the respective plant sources. In this regard, existing alternatives for resupply are also discussed, including different biotechnology approaches and total organic synthesis. While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.

Twitter Demographics

The data shown below were collected from the profiles of 10,229 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 730 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 <1%
Mexico 3 <1%
India 3 <1%
Germany 2 <1%
Serbia 2 <1%
Brazil 2 <1%
Indonesia 1 <1%
South Africa 1 <1%
Denmark 1 <1%
Other 15 2%
Unknown 695 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 151 21%
Student > Ph. D. Student 143 20%
Researcher 101 14%
Student > Bachelor 92 13%
Student > Doctoral Student 64 9%
Other 179 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 193 26%
Chemistry 158 22%
Biochemistry, Genetics and Molecular Biology 87 12%
Pharmacology, Toxicology and Pharmaceutical Science 84 12%
Unspecified 70 10%
Other 138 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 4556. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2018.
All research outputs
#40
of 11,397,023 outputs
Outputs from Biotechnology Advances
#1
of 904 outputs
Outputs of similar age
#1
of 236,132 outputs
Outputs of similar age from Biotechnology Advances
#1
of 16 outputs
Altmetric has tracked 11,397,023 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 904 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.