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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The structural biology of biosynthetic megaenzymes
|
|---|---|
| Published in |
Nature Chemical Biology, August 2015
|
| DOI | 10.1038/nchembio.1883 |
| Pubmed ID | |
| Authors |
Kira J Weissman |
| Abstract |
The modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are among the largest and most complicated enzymes in nature. In these biosynthetic systems, independently folding protein domains, which are organized into units called 'modules', operate in assembly-line fashion to construct polymeric chains and tailor their functionalities. Products of PKSs and NRPSs include a number of blockbuster medicines, and this has motivated researchers to understand how they operate so that they can be modified by genetic engineering. Beginning in the 1990s, structural biology has provided a number of key insights. The emerging picture is one of remarkable dynamics and conformational programming in which the chemical states of individual catalytic domains are communicated to the others, configuring the modules for the next stage in the biosynthesis. This unexpected level of complexity most likely accounts for the low success rate of empirical genetic engineering experiments and suggests ways forward for productive megaenzyme synthetic biology. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 11% |
| United States | 1 | 11% |
| Australia | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 401 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | <1% |
| United States | 4 | <1% |
| United Kingdom | 2 | <1% |
| Switzerland | 1 | <1% |
| Denmark | 1 | <1% |
| Russia | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| Poland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 385 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 116 | 29% |
| Student > Master | 62 | 15% |
| Researcher | 54 | 13% |
| Student > Bachelor | 52 | 13% |
| Student > Doctoral Student | 22 | 5% |
| Other | 41 | 10% |
| Unknown | 54 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 114 | 28% |
| Biochemistry, Genetics and Molecular Biology | 99 | 25% |
| Chemistry | 84 | 21% |
| Immunology and Microbiology | 13 | 3% |
| Environmental Science | 6 | 1% |
| Other | 20 | 5% |
| Unknown | 65 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2020.
All research outputs
#2,653,907
of 22,824,164 outputs
Outputs from Nature Chemical Biology
#1,416
of 3,060 outputs
Outputs of similar age
#36,236
of 266,186 outputs
Outputs of similar age from Nature Chemical Biology
#29
of 72 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.