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Attention Score in Context
| Title |
Role of osteopontin in bone remodeling and orthodontic tooth movement: a review
|
|---|---|
| Published in |
Progress in Orthodontics, June 2018
|
| DOI | 10.1186/s40510-018-0216-2 |
| Pubmed ID | |
| Authors |
Amarjot Singh, Gurveen Gill, Harsimrat Kaur, Mohamed Amhmed, Harpal Jakhu |
| Abstract |
In this review, most of the known and postulated mechanisms of osteopontin (OPN) and its role in bone remodeling and orthodontic tooth movement are discussed based on available literature. OPN, a multifunctional protein, is considered crucial for bone remodeling, biomineralization, and periodontal remodeling during mechanical tension and stress (orthodontic tooth movement). It contributes to bone remodeling by promoting osteoclastogenesis and osteoclast activity through CD44- and αvβ3-mediated cell signaling. Further, it has a definitive role in bone remodeling by the formation of podosomes, osteoclast survival, and osteoclast motility. OPN has been shown to have a regulatory effect on hydroxyapatite crystal (HAP) growth and potently inhibits the mineralization of osteoblast cultures in a phosphate-dependent manner. Bone remodeling is vital for orthodontic tooth movement. Significant compressive and tensional forces on the periodontium induce the signaling pathways mediated by various osteogenic genes including OPN, bone sialoprotein, Osterix, and osteocalcin. The signaling pathways involved in the regulation of OPN and its effect on the periodontal tissues during orthodontic tooth movement are further discussed in this review. A limited number of studies have suggested the use of OPN as a biomarker to assess orthodontic treatment. Furthermore, the association of single nucleotide polymorphisms (SNPs) in OPN coding gene Spp1 with orthodontically induced root resorption remains largely unexplored. Accordingly, future research directions for OPN are outlined in this review. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| South Africa | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 232 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 12% |
| Student > Ph. D. Student | 27 | 12% |
| Student > Bachelor | 19 | 8% |
| Researcher | 18 | 8% |
| Student > Doctoral Student | 13 | 6% |
| Other | 24 | 10% |
| Unknown | 103 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 25% |
| Biochemistry, Genetics and Molecular Biology | 24 | 10% |
| Engineering | 9 | 4% |
| Materials Science | 8 | 3% |
| Agricultural and Biological Sciences | 7 | 3% |
| Other | 16 | 7% |
| Unknown | 110 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2021.
All research outputs
#7,167,608
of 25,709,917 outputs
Outputs from Progress in Orthodontics
#43
of 255 outputs
Outputs of similar age
#114,595
of 343,241 outputs
Outputs of similar age from Progress in Orthodontics
#1
of 9 outputs
Altmetric has tracked 25,709,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 255 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them