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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Status of nutrients important in brain function in phenylketonuria: a systematic review and meta-analysis
|
|---|---|
| Published in |
Orphanet Journal of Rare Diseases, June 2018
|
| DOI | 10.1186/s13023-018-0839-x |
| Pubmed ID | |
| Authors |
Gina A. Montoya Parra, Rani H. Singh, Aysun Cetinyurek-Yavuz, Mirjam Kuhn, Anita MacDonald |
| Abstract |
Despite early and ongoing dietary management with a phe-restricted diet, suboptimal neuropsychological function has been observed in PKU. The restrictive nature of the PKU diet may expose patients to sub-optimal nutritional intake and deficiencies which may impact normal brain function. A systematic review of the published literature was carried out, where possible with meta-analysis, to compare the status of nutrients (Nutrients: DHA, EPA phospholipids, selenium, vitamins B6, B12, E, C, A, D, folic acid, choline, uridine, calcium, magnesium, zinc, iron, iodine and cholesterol) known to be important for brain development and functioning between individuals with PKU and healthy controls. Of 1534 publications identified, 65 studies met the entry criteria. Significantly lower levels of DHA, EPA and cholesterol were found for PKU patients compared to healthy controls. No significant differences in zinc, vitamins B12, E and D, calcium, iron and magnesium were found between PKU patients and controls. Because of considerable heterogeneity, the meta-analyses findings for folate and selenium were not reported. Due to an insufficient number of publications (< 4) no meta-analysis was undertaken for vitamins A, C and B6, choline, uridine, iodine and phospholipids. The current data show that PKU patients have lower availability of DHA, EPA and cholesterol. Compliance with the phe-restricted diet including the micronutrient fortified protein substitute (PS) is essential to ensure adequate micronutrient status. Given the complexity of the diet, patients' micronutrient and fatty acid status should be continuously monitored, with a particular focus on patients who are non-compliant or poorly compliant with their PS. Given their key role in brain function, assessment of the status of nutrients where limited data was found (e.g. choline, iodine) should be undertaken. Standardised reporting of studies in PKU would strengthen the output of meta-analysis and so better inform best practice for this rare condition. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 19% |
| Ireland | 2 | 8% |
| Mexico | 2 | 8% |
| United Kingdom | 2 | 8% |
| Netherlands | 2 | 8% |
| Belgium | 1 | 4% |
| Unknown | 12 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 69% |
| Practitioners (doctors, other healthcare professionals) | 5 | 19% |
| Scientists | 3 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 12% |
| Student > Ph. D. Student | 11 | 10% |
| Student > Master | 11 | 10% |
| Researcher | 10 | 9% |
| Other | 9 | 8% |
| Other | 10 | 9% |
| Unknown | 46 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 19% |
| Nursing and Health Professions | 11 | 10% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Agricultural and Biological Sciences | 5 | 5% |
| Psychology | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 47 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2020.
All research outputs
#2,126,745
of 25,732,188 outputs
Outputs from Orphanet Journal of Rare Diseases
#241
of 3,179 outputs
Outputs of similar age
#42,571
of 343,612 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#4
of 45 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,179 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.