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Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology

Overview of attention for article published in mSphere, August 2015
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Title
Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology
Published in
mSphere, August 2015
DOI 10.1128/cvi.00390-15
Pubmed ID
Authors

Hugh W F Kingston, Stuart D Blacksell, Ampai Tanganuchitcharnchai, Achara Laongnualpanich, Buddha Basnyat, Nicholas P J Day, Daniel H Paris

Abstract

This study investigated the comparative accuracy of a recombinant p56 kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies using conventional serology, in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy with 82% sensitivity and 98% specificity for samples defined positive at the IgM IFA positivity cutoff titer of ≥1:1,600, versus 92% and 95% at ≥1:6,400, respectively.

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Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 29%
Student > Master 5 16%
Other 3 10%
Student > Ph. D. Student 3 10%
Student > Bachelor 2 6%
Other 3 10%
Unknown 6 19%
Readers by discipline Count As %
Medicine and Dentistry 12 39%
Biochemistry, Genetics and Molecular Biology 5 16%
Immunology and Microbiology 2 6%
Agricultural and Biological Sciences 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Other 2 6%
Unknown 7 23%