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A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics

Overview of attention for article published in International Journal of Medical Sciences, January 2018
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Title
A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics
Published in
International Journal of Medical Sciences, January 2018
DOI 10.7150/ijms.25004
Pubmed ID
Authors

Ravichandra Vemuri, Tanvi Shinde, Madhur D Shastri, Agampodi Promoda Perera, Stephen Tristram, Christopher J Martoni, Rohit Gundamaraju, Kiran D K Ahuja, Madeleine Ball, Rajaraman Eri

Abstract

Background: The health benefits of probiotics are well established and known to be strain-specific. However, the role of probiotics obtained from different origins and their efficacy largely remains unexplored. The aim of this study is to investigate the in vitro efficacy of probiotics from different origins. Methods: Probiotic strains utilized in this study include Lactobacillus acidophilus DDS-1 (human origin), Bifidobacterium animalis ssp. lactis UABla-12 (human origin), L. plantarum UALp-05 (plant origin) and Streptococcus thermophilus UASt-09 (dairy origin). Screening assays such as in vitro digestion simulation, adhesion, cell viability and cytokine release were used to evaluate the probiotic potential. Results: All strains showed good resistance in the digestion simulation process, especially DDS-1 and UALp-05, which survived up to a range of 107 to 108 CFU/mL from an initial concentration of 109 CFU/mL. Two human colonic mucus-secreting cells, HT-29 and LS174T, were used to assess the adhesion capacity, cytotoxicity/viability, and cytokine quantification. All strains exhibited good adhesion capacity. No significant cellular cytotoxicity or loss in cell viability was observed. DDS-1 and UALp-05 significantly upregulated anti-inflammatory IL-10 and downregulated pro-inflammatory TNF-α cytokine production. All the strains were able to downregulate IL-8 cytokine levels. Conclusion: Of the 4 strains tested, DDS-1 demonstrated superior survival rates, good adhesion capacity and strong immunomodulatory effect under different experimental conditions.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 27%
Unspecified 3 20%
Lecturer > Senior Lecturer 2 13%
Student > Master 2 13%
Researcher 2 13%
Other 2 13%
Readers by discipline Count As %
Unspecified 4 27%
Biochemistry, Genetics and Molecular Biology 4 27%
Immunology and Microbiology 3 20%
Agricultural and Biological Sciences 2 13%
Chemistry 1 7%
Other 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2018.
All research outputs
#9,895,035
of 12,358,097 outputs
Outputs from International Journal of Medical Sciences
#253
of 428 outputs
Outputs of similar age
#198,937
of 267,762 outputs
Outputs of similar age from International Journal of Medical Sciences
#1
of 1 outputs
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So far Altmetric has tracked 428 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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