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Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Overview of attention for article published in Genes & Development, August 2015
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Mentioned by

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3 tweeters

Citations

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21 Dimensions

Readers on

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57 Mendeley
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Title
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
Published in
Genes & Development, August 2015
DOI 10.1101/gad.262568.115
Pubmed ID
Authors

Enrico Caserta, Onur Egriboz, Hui Wang, Chelsea Martin, Christopher Koivisto, Thierry Pecót, Raleigh D. Kladney, Changxian Shen, Kang-Sup Shim, Thac Pham, Matthew K. Karikomi, Melissa J. Mauntel, Sarmila Majumder, Maria C. Cuitino, Xing Tang, Arunima Srivastava, Lianbo Yu, Julie Wallace, Xiaokui Mo, Morag Park, Soledad A. Fernandez, Robert Pilarski, Krista M.D. La Perle, Thomas J. Rosol, Vincenzo Coppola, Diego H. Castrillon, Cynthia Timmers, David E. Cohn, David M. O'Malley, Floor Backes, Adrian A. Suarez, Paul Goodfellow, Helen M. Chamberlin, Erin R. Macrae, Charles L. Shapiro, Michael C. Ostrowski, Gustavo Leone

Abstract

Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K-AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 (Pten(FV)), found in human cancer. Despite having reduced levels of PTEN protein, homozygous Pten(FV/FV) embryos have intact AKT signaling, develop normally, and are carried to term. Heterozygous Pten(FV/+) mice develop carcinoma in the thymus, stomach, adrenal medulla, and mammary gland but not in other organs typically sensitive to Pten deficiency, including the thyroid, prostate, and uterus. Progression to carcinoma in sensitive organs ensues in the absence of overt AKT activation. Carcinoma in the uterus, a cancer-resistant organ, requires a second clonal event associated with the spontaneous activation of AKT and downstream signaling. In summary, this PTEN noncatalytic missense mutation exposes a core tumor suppressor function distinct from inhibition of canonical AKT signaling that predisposes to organ-selective cancer development in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Other 10 18%
Student > Ph. D. Student 9 16%
Student > Bachelor 5 9%
Student > Master 4 7%
Other 13 23%
Unknown 4 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 32%
Agricultural and Biological Sciences 10 18%
Medicine and Dentistry 10 18%
Environmental Science 3 5%
Engineering 3 5%
Other 8 14%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2015.
All research outputs
#7,434,881
of 12,367,469 outputs
Outputs from Genes & Development
#4,097
of 4,996 outputs
Outputs of similar age
#118,087
of 242,132 outputs
Outputs of similar age from Genes & Development
#32
of 48 outputs
Altmetric has tracked 12,367,469 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,996 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,132 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.