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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential preservation of endogenous human and microbial DNA in dental calculus and dentin
|
|---|---|
| Published in |
Scientific Reports, June 2018
|
| DOI | 10.1038/s41598-018-28091-9 |
| Pubmed ID | |
| Authors |
Allison E. Mann, Susanna Sabin, Kirsten Ziesemer, Åshild J. Vågene, Hannes Schroeder, Andrew T. Ozga, Krithivasan Sankaranarayanan, Courtney A. Hofman, James A. Fellows Yates, Domingo C. Salazar-García, Bruno Frohlich, Mark Aldenderfer, Menno Hoogland, Christopher Read, George R. Milner, Anne C. Stone, Cecil M. Lewis, Johannes Krause, Corinne Hofman, Kirsten I. Bos, Christina Warinner |
| Abstract |
Dental calculus (calcified dental plaque) is prevalent in archaeological skeletal collections and is a rich source of oral microbiome and host-derived ancient biomolecules. Recently, it has been proposed that dental calculus may provide a more robust environment for DNA preservation than other skeletal remains, but this has not been systematically tested. In this study, shotgun-sequenced data from paired dental calculus and dentin samples from 48 globally distributed individuals are compared using a metagenomic approach. Overall, we find DNA from dental calculus is consistently more abundant and less contaminated than DNA from dentin. The majority of DNA in dental calculus is microbial and originates from the oral microbiome; however, a small but consistent proportion of DNA (mean 0.08 ± 0.08%, range 0.007-0.47%) derives from the host genome. Host DNA content within dentin is variable (mean 13.70 ± 18.62%, range 0.003-70.14%), and for a subset of dentin samples (15.21%), oral bacteria contribute > 20% of total DNA. Human DNA in dental calculus is highly fragmented, and is consistently shorter than both microbial DNA in dental calculus and human DNA in paired dentin samples. Finally, we find that microbial DNA fragmentation patterns are associated with guanine-cytosine (GC) content, but not aspects of cellular structure. |
X Demographics
The data shown below were collected from the profiles of 50 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 14% |
| United Kingdom | 5 | 10% |
| Canada | 2 | 4% |
| Germany | 2 | 4% |
| Spain | 2 | 4% |
| Hong Kong | 1 | 2% |
| Argentina | 1 | 2% |
| Thailand | 1 | 2% |
| India | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 22 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 80% |
| Scientists | 9 | 18% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 132 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 19% |
| Student > Bachelor | 16 | 12% |
| Researcher | 15 | 11% |
| Student > Master | 14 | 11% |
| Student > Doctoral Student | 6 | 5% |
| Other | 20 | 15% |
| Unknown | 36 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 21% |
| Agricultural and Biological Sciences | 19 | 14% |
| Medicine and Dentistry | 11 | 8% |
| Social Sciences | 7 | 5% |
| Arts and Humanities | 7 | 5% |
| Other | 17 | 13% |
| Unknown | 43 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2023.
All research outputs
#934,906
of 24,892,887 outputs
Outputs from Scientific Reports
#9,753
of 136,347 outputs
Outputs of similar age
#20,416
of 335,382 outputs
Outputs of similar age from Scientific Reports
#247
of 3,521 outputs
Altmetric has tracked 24,892,887 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 136,347 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,382 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 3,521 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.