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Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics

Overview of attention for article published in British Journal of Clinical Pharmacology, November 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
9 tweeters

Citations

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6 Dimensions

Readers on

mendeley
34 Mendeley
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Title
Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics
Published in
British Journal of Clinical Pharmacology, November 2015
DOI 10.1111/bcp.12753
Pubmed ID
Authors

Maria D. Donovan, Geraldine B. Boylan, Deirdre M. Murray, John F. Cryan, Brendan T. Griffin

Abstract

A major consideration in the treatment of neonatal disorders is that the selected drug, dose and dosage frequency is safe, effective and appropriate for the intended patient population. Thus, a thorough knowledge of the pharmacokinetics and pharmacodynamics of the chosen drug within the patient-population is essential. In paediatric and especially neonatal populations, two additional challenges can often complicate drug treatment-the inherently greater physiological variability, and a lack of robust clinical evidence of therapeutic range. There has traditionally been an overreliance in paediatric medicine on extrapolating doses from adult values by adjusting for bodyweight or body surface area, but many other sources of variability exist which complicate the choice of dose in neonates. The lack of reliable drug dosage data in neonates has been highlighted by regulatory authorities, as only ~50% of the most commonly used paediatric medicines have been examined in a paediatric population. Moreover, there is a paucity of information on the pharmacokinetic parameters which affect drug concentrations in different body tissues, and pharmacodynamic responses to drugs in the neonate. Thus, in this review we draw attention to the main pharmacokinetic factors that influence the unbound brain concentration of neuro-active drugs. Moreover, the pharmacodynamic differences between neonates and adults that affect activity of centrally-acting therapeutic agents are briefly examined, with a particular emphasis on anti-epileptic drugs. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
United States 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Other 4 12%
Lecturer > Senior Lecturer 3 9%
Student > Bachelor 3 9%
Researcher 3 9%
Other 12 35%
Unknown 3 9%
Readers by discipline Count As %
Medicine and Dentistry 14 41%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Psychology 3 9%
Engineering 2 6%
Mathematics 1 3%
Other 4 12%
Unknown 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#4,262,121
of 15,927,389 outputs
Outputs from British Journal of Clinical Pharmacology
#1,234
of 4,004 outputs
Outputs of similar age
#62,572
of 241,095 outputs
Outputs of similar age from British Journal of Clinical Pharmacology
#24
of 72 outputs
Altmetric has tracked 15,927,389 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 4,004 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,095 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.