Title |
Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma
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Published in |
Biological Research, August 2015
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DOI | 10.1186/s40659-015-0038-3 |
Pubmed ID | |
Authors |
Zhao Yang, Bing Zhuan, Ying Yan, Simin Jiang, Tao Wang |
Abstract |
Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV). A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity IIIa, receptor (FCGR3A)], starch and sucrose metabolism [e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA1, GATA2, GATA3) jointly regulated the expression of TP63. The above CNV-driven genes might be potential contributors to the development of lung SCC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 24% |
Student > Ph. D. Student | 5 | 20% |
Student > Doctoral Student | 3 | 12% |
Student > Master | 3 | 12% |
Student > Bachelor | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 16% |
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Agricultural and Biological Sciences | 3 | 12% |
Neuroscience | 1 | 4% |
Materials Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 4 | 16% |