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Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth

Overview of attention for article published in BMC Pregnancy and Childbirth, August 2015
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Title
Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth
Published in
BMC Pregnancy and Childbirth, August 2015
DOI 10.1186/s12884-015-0627-8
Pubmed ID
Authors

Timothy H. Ciesielski, Carmen J. Marsit, Scott M. Williams

Abstract

We sought to identify and characterize predictors of poor fetal growth among variables extracted from perinatal medical records to gain insight into potential etiologic mechanisms. In this process we reevaluated a previously observed association between poor fetal growth and maternal psychiatric disease. We evaluated 449 deliveries of >36 weeks gestation that occurred between 9/2008 and 9/2010 at the Women and Infants Hospital in Providence Rhode Island. This study group was oversampled for Small-for-Gestational-Age (SGA) infants and excluded Large-for-Gestational-Age (LGA) infants. We assessed the associations between recorded clinical variables and impaired fetal growth: SGA or Intrauterine Growth Restriction (IUGR) diagnosis. After validating the previously observed association between maternal psychiatric disease and impaired fetal growth we addressed weaknesses in the prior studies by explicitly considering antidepressant use and the timing of symptoms with respect to pregnancy. We then evaluated DNA methylation levels at 27 candidate loci in placenta from a subset of these deliveries (n = 197) to examine if epigenetic variation could provide insight into the mechanisms that cause this co-morbidity. Infants of mothers with prenatal psychiatric disease (Depression, Anxiety, OCD/Panic) had increased odds of poor fetal growth (ORadjusted = 3.36, 95%CI: 1.38-8.14). This relationship was similar among those who were treated with antidepressants (ORadjusted = 3.69, 95%CI: 1.31-10.45) and among those who were not (ORadjusted = 3.19, 95%CI: 1.30-7.83). Among those with a history of psychiatric disease but no active disease in pregnancy the ORadjusted was 0.45 (95%CI: 0.09-2.35). A locus near the transcription start site of the leptin receptor (cg21655790) had methylation levels that were decreased in the presence of: 1) SGA/IUGR, and 2) active but not resolved psychiatric disease (among mothers not on antidepressants). These results validate and further characterize the association between maternal psychiatric disease and poor fetal growth. Because the association appears to depend on active psychiatric disease, this suggests a transient and potentially modifiable pathophysiology. The molecular findings in this study suggest that altered leptin signaling may be involved in the biological mechanisms that link prenatal maternal psychiatric symptoms and poor fetal growth.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Unknown 148 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 15%
Student > Master 21 14%
Student > Bachelor 21 14%
Other 12 8%
Student > Doctoral Student 10 7%
Other 23 15%
Unknown 39 26%
Readers by discipline Count As %
Medicine and Dentistry 39 26%
Psychology 16 11%
Neuroscience 11 7%
Biochemistry, Genetics and Molecular Biology 9 6%
Nursing and Health Professions 7 5%
Other 21 14%
Unknown 46 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2015.
All research outputs
#14,556,454
of 23,312,088 outputs
Outputs from BMC Pregnancy and Childbirth
#2,769
of 4,285 outputs
Outputs of similar age
#140,200
of 268,581 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#57
of 93 outputs
Altmetric has tracked 23,312,088 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,285 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,581 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.