Title |
Hydrocortisone supresses inflammatory activity of metalloproteinase - 8 in carotid plaque
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Published in |
Revista Brasileira de Cirurgia Cardiovascular, January 2015
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DOI | 10.5935/1678-9741.20150034 |
Pubmed ID | |
Authors |
Sthefano Atique Gabriel, Leila Antonangelo, Vera Luiza Capelozzi, Camila Baumann Beteli, Otacílio de Camargo, José Luis Braga de Aquino, Roberto Augusto Caffaro |
Abstract |
Matrix metalloproteinases are inflammatory biomarkers involved in carotid plaque instability. Our objective was to analyze the inflammatory activity of plasma and carotid plaque MMP-8 and MMP-9 after intravenous administration of hydrocortisone. The study included 22 patients with stenosis ≥ 70% in the carotid artery (11 symptomatic and 11 asymptomatic) who underwent carotid endarterectomy. The patients were divided into two groups: Control Group - hydrocortisone was not administered, and Group 1 - 500 mg intravenous hydrocortisone was administered during anesthetic induction. Plasma levels of MMP-8 and MMP-9 were measured preoperatively (24 hours before carotid endarterectomy) and at 1 hour, 6 hours and 24 hours after carotid endarterectomy. In carotid plaque, tissue levels of MMP-8 and MMP-9 were measured. Group 1 showed increased serum levels of MMP- 8 (994.28 pg/ml and 408.54 pg/ml, respectively; P=0.045) and MMP-9 (106,656.34 and 42,807.69 respectively; P=0.014) at 1 hour after carotid endarterectomy compared to the control group. Symptomatic patients in Group 1 exhibited lower tissue concentration of MMP-8 in comparison to the control group (143.89 pg/ml and 1317.36 respectively; P=0.003). There was a correlation between preoperative MMP-9 levels and tissue concentrations of MMP-8 (P=0.042) and MMP-9 (P=0.019) between symptomatic patients in the control group. Hydrocortisone reduces the concentration of MMP- 8 in carotid plaque, especially in symptomatic patients. There was an association between systemic and tissue inflammation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 1 | 9% |
Student > Doctoral Student | 1 | 9% |
Student > Bachelor | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Researcher | 1 | 9% |
Other | 0 | 0% |
Unknown | 6 | 55% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 27% |
Neuroscience | 1 | 9% |
Unknown | 7 | 64% |