Title |
The sample that would not clot
|
---|---|
Published in |
Clinica Chimica Acta, June 2018
|
DOI | 10.1016/j.cca.2018.06.026 |
Pubmed ID | |
Authors |
Sydney W Strickland, Emily Burns, Surabhi Palkimas, Lindsay A L Bazydlo |
Abstract |
Vitamin K is a vital component within both the intrinsic and extrinsic coagulation cascade as certain factors (II, VII, IX, X and protein C and S) utilize vitamin K as a cofactor during post translational modification. Deficiency of vitamin K can result in the inability to properly form blood clots, both in vivo and in vitro, due to reduced vitamin K dependent factor levels and function. Vitamin K deficiency can result from congenital causes, such as VKOR or CYP2C9 mutations, or acquired causes, such as nutritional deficiencies, antibiotic therapy, or supra-therapeutic warfarin dosing. In this case we present a patient with multifactorial vitamin K deficiency (due to nutritional defects and multiple genetic mutations in VKOR and CYP2C9) that was exacerbated by antibiotic and warfarin therapy during her hospital admission. This case displays the importance of genetic testing prior to warfarin dosing and the role antibiotics play in the coagulation cascade. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 14% |
Student > Master | 2 | 9% |
Student > Bachelor | 2 | 9% |
Unspecified | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 2 | 9% |
Unknown | 11 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Unspecified | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 45% |