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The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease

Overview of attention for article published in Diabetology & Metabolic Syndrome, June 2018
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2 tweeters
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1 Facebook page

Citations

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10 Dimensions

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32 Mendeley
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Title
The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease
Published in
Diabetology & Metabolic Syndrome, June 2018
DOI 10.1186/s13098-018-0353-2
Pubmed ID
Authors

Fariba Raygan, Zohreh Rezavandi, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mohammad Ali Mansournia, Maryam Tajabadi-Ebrahimi, Shokoofeh Borzabadi, Zatollah Asemi

Abstract

This study was conducted to evaluate the effects of probiotic supplementation on metabolic profiles in diabetic patients with coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed among 60 diabetic patients with CHD, aged 40-85 years at a cardiology clinic in Kashan, Iran, from October 2017 through January 2018. Patients were randomly divided into two groups to take either probiotic supplements (n = 30) or placebo (n = 30) for 12 weeks. Fasting blood samples were taken at the beginning of the study and after the 12-week intervention to determine related markers. After 12-week intervention, probiotic supplementation significantly decreased fasting plasma glucose (β - 20.02 mg/dL; 95% CI - 33.86, - 6.17; P = 0.005), insulin (β - 2.09 µIU/mL; 95% CI - 3.77, - 0.41; P = 0.01), insulin resistance (β - 0.50; 95% CI - 0.96, - 0.03; P = 0.03) and total-/HDL-cholesterol ratio (β - 0.27; 95% CI - 0.52, - 0.03; P = 0.02), and significantly increased insulin sensitivity (β 0.008; 95% CI 0.001, 0.01; P = 0.02) and HDL-cholesterol levels (β 2.52 mg/dL; 95% CI 0.04, 5.00; P = 0.04) compared with the placebo. Moreover, probiotic supplementation led to a significant reduction in serum high sensitivity C-reactive protein (β - 0.88 mg/L; 95% CI - 1.39, - 0.38; P = 0.001), and a significant elevation in total antioxidant capacity (β 108.44 mmol/L; 95% CI 47.61, 169.27; P = 0.001) and total glutathione levels (β 45.15 µmol/L; 95% CI 5.82, 84.47; P = 0.02) compared with the placebo. Probiotic supplementation did not affect other metabolic profiles. Overall, we found that probiotic supplementation for 12 weeks had beneficial effects on glycemic control, HDL-cholesterol, total-/HDL-cholesterol ratio, biomarkers of inflammation and oxidative stress in diabetic patients with CHD.Trial registration Clinical trial registration number http://www.irct.ir: IRCT2017082733941N5.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 28%
Student > Ph. D. Student 5 16%
Student > Doctoral Student 4 13%
Student > Master 2 6%
Professor 2 6%
Other 3 9%
Unknown 7 22%
Readers by discipline Count As %
Medicine and Dentistry 9 28%
Nursing and Health Professions 9 28%
Agricultural and Biological Sciences 1 3%
Psychology 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 1 3%
Unknown 10 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2018.
All research outputs
#7,957,214
of 13,845,249 outputs
Outputs from Diabetology & Metabolic Syndrome
#181
of 405 outputs
Outputs of similar age
#140,735
of 273,500 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#1
of 1 outputs
Altmetric has tracked 13,845,249 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 405 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,500 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them